Effect of taurine on rat Achilles tendon healing

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dc.contributor.authorAkdemir O.
dc.contributor.authorLineaweaver W.C.
dc.contributor.authorCavusoglu T.
dc.contributor.authorBinboga E.
dc.contributor.authorUyanikgil Y.
dc.contributor.authorZhang F.
dc.contributor.authorPekedis M.
dc.contributor.authorYagci T.
dc.date.accessioned2019-10-26T21:26:51Z
dc.date.available2019-10-26T21:26:51Z
dc.date.issued2015
dc.departmentEge Üniversitesien_US
dc.description.abstractTaurine has anti-inflammatory and antioxidant characteristics. We have introduced taurine into a tendon-healing model to evaluate its effects on tendon healing and adhesion formation. Two groups of 16 rats underwent diversion and repair of the Achilles tendon. One group received a taurine injection (200mg/ml) at the repair site, while the other group received 1ml of saline. Specimens were harvested at 6 weeks and underwent biomechanical and histological evaluation. No tendon ruptured. Average maximum load was significantly greater in the taurine-applied group compared with the control group (p<0.05). Similarly, average energy uptake was significantly higher in the taurine-applied group compared with the control group (p<0.05). We observed no significant differences in stiffness in both groups (p>0.05). After histological assessment, we found that fibroblast proliferation, edema, and inflammation statistically decreased in the treatment group (p<0.05). These findings could indicate greater tendon strength with less adhesion formation, and taurine may have an effect on adhesion formation. © 2015 Informa Healthcare USA, Inc.en_US
dc.identifier.doi10.3109/03008207.2015.1026437en_US
dc.identifier.endpage306en_US
dc.identifier.issn0300-8207
dc.identifier.issue4en_US
dc.identifier.pmid25749029en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage300en_US
dc.identifier.urihttps://doi.org/10.3109/03008207.2015.1026437
dc.identifier.urihttps://hdl.handle.net/11454/17376
dc.identifier.volume56en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor and Francis Ltden_US
dc.relation.ispartofConnective Tissue Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAntiadhesionen_US
dc.subjectfibrosisen_US
dc.subjectratsen_US
dc.subjecttaurineen_US
dc.subjecttendon healingen_US
dc.titleEffect of taurine on rat Achilles tendon healingen_US
dc.typeArticleen_US

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