Constructive effect of exogenous melatonin against osteoporosis after ovariectorny in rats

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dc.contributor.authorUslu, Serap
dc.contributor.authorUysal, Ayseguel
dc.contributor.authorOektem, Guelperi
dc.contributor.authorYurtseven, Mine
dc.contributor.authorTanyalcin, Tijen
dc.contributor.authorBasdemir, Guelcin
dc.date.accessioned2019-10-27T20:00:46Z
dc.date.available2019-10-27T20:00:46Z
dc.date.issued2007
dc.departmentEge Üniversitesien_US
dc.description.abstractOBJECTIVE: To analyze histomorphometric, densitometric and biochemical effects of melatonin on osteoporosis in ovariectomized rats. STUDY DESIGN: Wistar rats were divided into 6 groups. Group C: control; Group I: bilateral ovariectomy (OVX); Group II. OVX + vehicle; Group III: OVX + 10 mg/kg/day melatonin WLT); Group IV. OVX + 30 mg/kg/day MLT; Group V. sham + 10 mg/kg/day MLT. Cortex, trabecula, osteoblast and osteoclast numbers were evaluated on vertebra and femur histomorphometrically. Hydroxyproline analysis was used to determine collagen content of femur and vertebrae. Bone mineral density and bone mineral content were measured. RESULTS: Trabecular thickness and trabecular area of vertebra and femur and cortical thickness of femur showed remarkable decrease after OVX, but increased after MLT treatment in the OVX+MLT groups. Following OVX, no statistically significant difference was found in number of osteoblasts or osteoclasts, trabecular number or levels of hydroxyproline after treatment with MLT. OVX caused significant decrease in bone mineral density, but treatment with MLT was unable to reverse this effect. CONCLUSION: MLT may trigger microscopic changes in bone, and time of application is critical for clinical recovery. It can be effective in helping treat postmenopausal osteoporosis. However, it is contraindicated in women who have normal-functioning ovaries.en_US
dc.identifier.endpage325en_US
dc.identifier.issn0884-6812
dc.identifier.issue5en_US
dc.identifier.pmid17987812en_US
dc.identifier.startpage317en_US
dc.identifier.urihttps://hdl.handle.net/11454/41221
dc.identifier.volume29en_US
dc.identifier.wosWOS:000250322300005en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSci Printers & Publ Incen_US
dc.relation.ispartofAnalytical and Quantitative Cytology and Histologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectbone histomorphometryen_US
dc.subjectbone mineral densityen_US
dc.subjecthydroxyprolineen_US
dc.subjectmelatoninen_US
dc.subjectosteoporosisen_US
dc.subjectovariectomyen_US
dc.titleConstructive effect of exogenous melatonin against osteoporosis after ovariectorny in ratsen_US
dc.typeArticleen_US

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