Nanostructured Amphiphilic Star-Hyperbranched Block Copolymers for Drug Delivery

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dc.contributor.authorSeleci, Muharrem
dc.contributor.authorSeleci, Didem Ag
dc.contributor.authorCiftci, Mustafa
dc.contributor.authorDemirkol, Dilek Odaci
dc.contributor.authorStahl, Frank
dc.contributor.authorTimur, Suna
dc.contributor.authorScheper, Thomas
dc.contributor.authorYagci, Yusuf
dc.date.accessioned2019-10-27T23:01:06Z
dc.date.available2019-10-27T23:01:06Z
dc.date.issued2015
dc.departmentEge Üniversitesien_US
dc.description.abstractA robust drug delivery system based on nanosized amphiphilic star-hyperbranched block copolymer, namely, poly(methyl methacrylate-block-poly(hydroxylethyl methacrylate) (PMMA-b-PHEMA) is described. PMMA-b-PHEMA was prepared by sequential visible light induced self-condensing vinyl polymerization (SCVP) and conventional vinyl polymerization. All of the synthesis and characterization details of the conjugates are reported. To accomplish tumor cell targeting property, initially cell-targeting (arginylglycylaspactic acid; RGD) and penetrating peptides (Cys-TAT) were binding to each other via the well-known EDC/NHS chemistry. Then, the resulting peptide was further incorporated to the surface of the amphiphilic hyperbranched copolymer via a coupling reaction between the thiol (-SH) group of the peptide and the hydroxyl group of copolymer by using N-(p-maleinimidophenyl) isocyanate as a heterolinker. The drug release property and targeting effect of the anticancer drug (doxorobucin; DOX) loaded nanostructures to two different cell lines were evaluated in vitro. U87 and MCF-7 were chosen as integrin alpha(v)beta(3) receptor positive and negative cells for the comparison of the targeting efficiency, respectively. The data showed that drug-loaded copolymers exhibited enhanced cell inhibition toward U87 cells in compared to MCF-7 cells because targeting increased the cytotoxicity of drug-loaded copolymers against integrin alpha(v)beta(3) receptor expressing tumor cells.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK)Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [113Z529, 113Z234]; Konrad Adenauer Foundation; TUBITAKTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK)en_US
dc.description.sponsorshipThis work was supported by Scientific and Technological Research Council of Turkey (TUBITAK, Project No. 113Z529 and 113Z234). Konrad Adenauer Foundation is acknowledged for the financial support to D.A.S. M.C. thanks TUBITAK for the financial support by means of a graduate program. The authors thank the Laboratory of Nano and Quantum Engineering (LNQE) of the Leibniz University of Hannover for TEM. M. Weiss (Leibniz University of Hannover, Institute for Technical Chemistry) is also acknowledged for technical help during HPLC analysis.en_US
dc.identifier.doi10.1021/acs.langmuir.5b00082en_US
dc.identifier.endpage4551en_US
dc.identifier.issn0743-7463
dc.identifier.issue15en_US
dc.identifier.pmid25816726en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage4542en_US
dc.identifier.urihttps://doi.org/10.1021/acs.langmuir.5b00082
dc.identifier.urihttps://hdl.handle.net/11454/52111
dc.identifier.volume31en_US
dc.identifier.wosWOS:000353429300021en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAmer Chemical Socen_US
dc.relation.ispartofLangmuiren_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleNanostructured Amphiphilic Star-Hyperbranched Block Copolymers for Drug Deliveryen_US
dc.typeArticleen_US

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