Transcoronary Gradients of Mechanosensitive MicroRNAs as Predictors of Collateral Development in Chronic Total Occlusion

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dc.authoridVural, Mustafa Gökhan/0000-0002-7055-0492
dc.contributor.authorVural, Mustafa Gokhan
dc.contributor.authorTemel, Hulya Yilmaz
dc.contributor.authorTurunc, Ezgi
dc.contributor.authorAkdemir, Ramazan
dc.contributor.authorTatli, Ersan
dc.contributor.authorAgac, Mustafa Tarik
dc.date.accessioned2024-08-31T07:47:45Z
dc.date.available2024-08-31T07:47:45Z
dc.date.issued2024
dc.departmentEge Üniversitesien_US
dc.description.abstractBackground and Objectives: In this present study, we investigated the impact of mechanosensitive microRNAs (mechano-miRs) on the collateral development in 126 chronic total occlusion (CTO) patients, selected from 810 undergoing angiography. Materials and Methods: We quantified the collateral blood supply using the collateral flow index (CFI) and assessed the transcoronary mechano-miR gradients. Results: The patients with favorable collaterals had higher CFI values (0.45 +/- 0.02) than those with poor collaterals (0.38 +/- 0.03, p < 0.001). Significant differences in transcoronary gradients were found for miR-10a, miR-19a, miR-21, miR-23b, miR-26a, miR-92a, miR-126, miR-130a, miR-663, and let7d (p < 0.05). miR-26a and miR-21 showed strong positive correlations with the CFI (r = 0.715 and r = 0.663, respectively), while let7d and miR-663 were negatively correlated (r = -0.684 and r = -0.604, respectively). The correlations between cytokine gradients and mechano-miR gradients were also significant, including Transforming Growth Factor Beta with miR-126 (r = 0.673, p < 0.001) and Vascular Endothelial Growth Factor with miR-10a (r = 0.602, p = 0.002). A regression analysis highlighted the hemoglobin level, smoking, beta-blocker use, miR-26a, and miR-663 as significant CFI determinants, indicating their roles in modulating the collateral vessel development. Conclusions: These findings suggest mechanosensitive microRNAs as predictive biomarkers for collateral circulation, offering new therapeutic perspectives for CTO patients.en_US
dc.description.sponsorshipTBIdot;TAKen_US
dc.description.sponsorshipNo Statement Availableen_US
dc.identifier.doi10.3390/medicina60040590
dc.identifier.issn1010-660X
dc.identifier.issn1648-9144
dc.identifier.issue4en_US
dc.identifier.pmid38674237en_US
dc.identifier.scopus2-s2.0-85191334413en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.3390/medicina60040590
dc.identifier.urihttps://hdl.handle.net/11454/104514
dc.identifier.volume60en_US
dc.identifier.wosWOS:001211223200001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMdpien_US
dc.relation.ispartofMedicina-Lithuaniaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz20240831_Uen_US
dc.subjectChronic Total Occlusionen_US
dc.subjectCollateral Flow Indexen_US
dc.subjectMechanosensitive Micrornasen_US
dc.subjectTranscoronary Gradienten_US
dc.subjectCoronary Collateral Developmenten_US
dc.subjectCytokinesen_US
dc.titleTranscoronary Gradients of Mechanosensitive MicroRNAs as Predictors of Collateral Development in Chronic Total Occlusionen_US
dc.typeArticleen_US

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