The interaction between antioxidant status and cervical cancer: a case control study

Basit Öğe Kaydı
dc.contributor.authorDemirci, Senem
dc.contributor.authorOzsaran, Zeynep
dc.contributor.authorCelik, Handan Ak
dc.contributor.authorAras, Arif Bulent
dc.contributor.authorAydin, Hikmet Hakan
dc.date.accessioned2019-10-27T21:24:17Z
dc.date.available2019-10-27T21:24:17Z
dc.date.issued2011
dc.departmentEge Üniversitesien_US
dc.description.abstractAims and background. To compare the antioxidant status of cervical cancer patients with healthy controls and to assess the antioxidant levels before and after radiotherapy or radiochemotherapy. Methods and study design. Antioxidant levels (glutathione, glutathione peroxidase, superoxide dismutase, and malondialdehyde) were measured in 35 patients with cervical cancer and 35 age-matched healthy controls. Blood samples were collected twice (before and after treatment) from cervical cancer patients and once from healthy control subjects. Results. In the patient group, pre-radiotherapy glutathione and glutathione peroxidase levels were significantly lower (P < 0.01 and P < 0.0001, respectively) than the control group. Pre-radiotherapy levels of superoxide dismutase were significantly higher in cancer patients (P < 0.01). In general, no difference was observed between pre- and post-radiotherapy antioxidant levels in cancer patients. However, when post-radiotherapy glutathione levels were analyzed, patients who did not respond to treatment had significantly higher levels than those who did respond (P < 0.01). Conclusions. Levels of antioxidants significantly differed between the patients with cervical cancer and the controls, and no change in antioxidant levels was observed after treatment. Moreover, further studies evaluating the predictive value of glutathione levels on treatment response are warranted.en_US
dc.description.sponsorshipEge University Scientific Research BoardEge University [2004-TIP-007]en_US
dc.description.sponsorshipThe study was supported by Ege University Scientific Research Board with project number of "2004-TIP-007". We gratefully thank the clinical nurses from the Department of Radiation Oncology Oya Bildik, Emine Kaya and Figan Gulersoy for their assistance. We also thank Nurten Cetiner, Asil Gonul, Tayyibe Yeni, Nurdan Guldiken and Ozge Tokul, from AREL (Research and Education Laboratory), Ege University School of Medicine, for their technical assistance.en_US
dc.identifier.endpage295en_US
dc.identifier.issn0300-8916
dc.identifier.issn2038-2529
dc.identifier.issue3en_US
dc.identifier.pmid21789005en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage290en_US
dc.identifier.urihttps://hdl.handle.net/11454/44472
dc.identifier.volume97en_US
dc.identifier.wosWOS:000293616300006en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWichtig Publen_US
dc.relation.ispartofTumorien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectantioxidant statusen_US
dc.subjectradiationen_US
dc.subjectuterine cervical neoplasmsen_US
dc.titleThe interaction between antioxidant status and cervical cancer: a case control studyen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu