Analysis of the antinociceptive effect of systemic administration of tramadol and dexmedetomidine combination on rat models of acute and neuropathic pain

Basit Öğe Kaydı
dc.contributor.authorGuneli, Ensari
dc.contributor.authorYavasoglu, N. Ulkue Karabay
dc.contributor.authorApaydin, Sebnem
dc.contributor.authorUyar, Meltem
dc.contributor.authorUyar, Mehmet
dc.date.accessioned2019-10-27T19:59:38Z
dc.date.available2019-10-27T19:59:38Z
dc.date.issued2007
dc.departmentEge Üniversitesien_US
dc.description.abstractThe aim of the present study was to investigate the possible antinociceptive effect of systemic administration of tramadol and dexmedetomidine either alone or in combination on acute and neuropathic pain models in rats. The antinociceptive effects of intraperitoneal (i.p.) tramadol (520 mg/kg) and dexmedetomidine (5-20 mu g/kg) and three different combinations of tramadol+dexmedetomidine (5 + 5, 5 + 10 and 10+ 5, mg/kg+ mu g/kg, respectively) were measured by tail-flick and hot-plate methods in acute pain. The effects on the sciatic nerve ligation-induced neuropathic pain was tested by i.p. administration of tramadol (5 mu g/kg), dexmedetomidine (5 mu g/kg) and tramadol + dexmedetomidine combination (5 + 5) using a thermal plantar test. Sedation/motor-incoordination was assessed on rotarod. Tramadol and dexmedetomidine produced dose-related antinociception in tail-flick and hot-plate tests. In both tests, combination of these drugs produced an antinociceptive effect that is greater than that produced by tramadol. or dexmedetomidine alone at several time points. In hot-plate test, tramadol + dexmedetomidine combination (5 + 10) exerted the strongest antinociceptive effect, while tramadol + dexmedetomidine combination (10 + 5) was significantly most effective in tail-flick test. In the neuropathic pain, the antinociceptive effect exerted by tramadol + dexmedetomidine combination (5 + 5) was also significantly greater than their applications alone. In rotarod test, tramadol (30 and 40 mg/kg), dexmedetomidine (30 and 40 mu g/kg), tramadol+dexmedetomidine combination (10+10, 20+20) produced sedation/motor-incoordination, whereas tramadol (5-20 mg/kg), dexmedetomidine (5-20 mu g/kg) and tramadol + dexmedetomidine combination (5 + 5, 5 + 10 and 10 + 5) did not produce any effect on sedation/motor-incoordination. The combination of tramadol and dexmedetomidine was more effective in increasing the pain threshold in acute and neuropathic pain when compared with the administration of either of these drugs alone. (C) 2007 Elsevier Inc. All rights reserved.en_US
dc.identifier.doi10.1016/j.pbb.2007.06.006en_US
dc.identifier.endpage17en_US
dc.identifier.issn0091-3057
dc.identifier.issue1en_US
dc.identifier.pmid17651791en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage9en_US
dc.identifier.urihttps://doi.org/10.1016/j.pbb.2007.06.006
dc.identifier.urihttps://hdl.handle.net/11454/41200
dc.identifier.volume88en_US
dc.identifier.wosWOS:000250099200002en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofPharmacology Biochemistry and Behavioren_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjecttramadolen_US
dc.subjectdexmedetomidineen_US
dc.subjectcombinationen_US
dc.subjectantinociceptionen_US
dc.subjectsedationen_US
dc.subjectacute painen_US
dc.subjectneuropathic painen_US
dc.subjectraten_US
dc.titleAnalysis of the antinociceptive effect of systemic administration of tramadol and dexmedetomidine combination on rat models of acute and neuropathic painen_US
dc.typeArticleen_US

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