Mobile Phone Sensing of Cocaine in a Lateral Flow Assay Combined with a Biomimetic Material

Basit Öğe Kaydı
dc.contributor.authorGuler, Emine
dc.contributor.authorSengel, Tulay Yilmaz
dc.contributor.authorGumus, Z. Pinar
dc.contributor.authorArslan, Mustafa
dc.contributor.authorCoskunol, Hakan
dc.contributor.authorTimur, Suna
dc.contributor.authorYagci, Yusuf
dc.date.accessioned2019-10-27T11:05:29Z
dc.date.available2019-10-27T11:05:29Z
dc.date.issued2017
dc.departmentEge Üniversitesien_US
dc.description.abstractLateral flow assays (LFAs) are an ideal choice for drug abuse testing favored by their practicability, portability, and rapidity. LFA based on site rapid screening devices provide positive/negative judgment in a short response time. The conventionally applied competitive assay format used for small molecule analysis such as abused drugs restricts the quantitation ability of LFA strips. We report herein, for the first time, a new strategy using the noncompetitive assay format via a biomimetic material, namely, poly(p-phenylene) beta-cyclodextrin poly(ethylene glycol) (PPP-CD-g-PEG) combined with gold nanoparticle (AuNP) conjugates as the labeling agent to recognize the target cocaine molecule in the test zone. The intensities of the visualized red color in the test line indicate that the cocaine concentrations were analyzed via a smartphone application. Significantly, a combination of this platform with a smartphone application provides quantitative data on the cocaine amount, making it a very inventive and attractive approach especially for on-site applications at critical points such as traffic stops and the workplace.en_US
dc.description.sponsorshipIndustrial Thesis Support Program (SAN-TEZ) of Republic of Turkey, Ministry of Science, Industry and Technology [0620.STZ.2014]; Republic of Turkey, Ministry of DevelopmentTurkiye Cumhuriyeti Kalkinma Bakanligi [2016K121190]; Ege University Research Fund through BAP projects [16-FEN-004, 14-FEN-019]; Istanbul Technical University Research Funden_US
dc.description.sponsorshipThis study was funded by Industrial Thesis Support Program (SAN-TEZ) of Republic of Turkey, Ministry of Science, Industry and Technology (Project Grant No: 0620.STZ.2014), and Republic of Turkey, Ministry of Development (Project Grant No: 2016K121190). It was also partially supported by Ege University Research Fund through BAP projects (Project No: 16-FEN-004 and Project No: 14-FEN-019) and Istanbul Technical University Research Fund.en_US
dc.identifier.doi10.1021/acs.analchem.7b03017en_US
dc.identifier.endpage9632en_US
dc.identifier.issn0003-2700
dc.identifier.issn1520-6882
dc.identifier.issue18en_US
dc.identifier.pmid28831804en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage9629en_US
dc.identifier.urihttps://doi.org/10.1021/acs.analchem.7b03017
dc.identifier.urihttps://hdl.handle.net/11454/31683
dc.identifier.volume89en_US
dc.identifier.wosWOS:000411549100005en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAmer Chemical Socen_US
dc.relation.ispartofAnalytical Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleMobile Phone Sensing of Cocaine in a Lateral Flow Assay Combined with a Biomimetic Materialen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu