Photoinduced in situ formation of clickable PEG hydrogels and their antibody conjugation

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dc.contributor.authorKahveci, Muhammet U.
dc.contributor.authorCiftci, Mustafa
dc.contributor.authorEvran, Serap
dc.contributor.authorTimur, Suna
dc.contributor.authorYagci, Yusuf
dc.date.accessioned2019-10-27T22:28:06Z
dc.date.available2019-10-27T22:28:06Z
dc.date.issued2015
dc.departmentEge Üniversitesien_US
dc.description.abstractA simple approach for the preparation of a clickable poly(ethylene glycol)-based hydrogel as a polymeric support for protein immobilization via photoinitiated free radical polymerization of poly(ethylene glycol) diacrylate and propargyl acrylate is established. Bioconjugation to the obtained gels was achieved by azide-alkyne click reaction with azido-functionalized anti-immunoglobulin G (anti-IgG) and anti-His tag antibodies. Evaluation of the affinities of the PEG hydrogels to the corresponding substrates (IgG and His-tagged YFP, respectively) indicates their specific binding capability.en_US
dc.description.sponsorshipIstanbul Technical University Research Fund; TUBITAK (The Scientific and Technical Research Council of Turkey)Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [113Z234]; TUBITAKTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK)en_US
dc.description.sponsorshipThe authors are thankful for Istanbul Technical University Research Fund and TUBITAK (The Scientific and Technical Research Council of Turkey) Project No. 113Z234. M.C. thanks TUBITAK for the financial support by means of a graduate program.en_US
dc.identifier.doi10.1080/15685551.2014.971392
dc.identifier.endpage136en_US
dc.identifier.issn1385-772X
dc.identifier.issn1568-5551
dc.identifier.issn1385-772Xen_US
dc.identifier.issn1568-5551en_US
dc.identifier.issue2en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage129en_US
dc.identifier.urihttps://doi.org/10.1080/15685551.2014.971392
dc.identifier.urihttps://hdl.handle.net/11454/50839
dc.identifier.volume18en_US
dc.identifier.wosWOS:000345688800004en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofDesigned Monomers and Polymersen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectprotein adsorptionen_US
dc.subjectclick chemistryen_US
dc.subjectbioconjugationen_US
dc.subjectphotopolymerizationen_US
dc.subjecthydrogelsen_US
dc.titlePhotoinduced in situ formation of clickable PEG hydrogels and their antibody conjugationen_US
dc.typeArticleen_US

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