Hypoxia-Inducible Factor 1 alpha and AT-Rich Interactive Domain-Containing Protein 1A Expression in Pituitary Adenomas: Association with Pathological, Clinical, and Radiological Features

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dc.contributor.authorKinali, Burak
dc.contributor.authorSenoglu, Mehmet
dc.contributor.authorKaradag, Fatma Keklik
dc.contributor.authorKaradag, Ali
dc.contributor.authorMiddlebrooks, Erik H.
dc.contributor.authorOksuz, Pinar
dc.contributor.authorSandal, Evren
dc.contributor.authorTurk, Caglar
dc.contributor.authorDiniz, Gulden
dc.date.accessioned2019-10-27T09:59:25Z
dc.date.available2019-10-27T09:59:25Z
dc.date.issued2019
dc.departmentEge Üniversitesien_US
dc.description.abstractBACKGROUND: Hypoxia-inducible factor (HIF) plays a major role in tumorigenesis and cancer progression. In hypoxic conditions, HIF is upregulated and has been shown to activate multiple genes required for cells to adapt to hypoxia. AT-rich interactive domain-containing protein 1A (ARID1A), a SWI/SNF (switch/sucrose nonfermentable) chromatin remodeling gene has context-dependent tumorsuppressive and oncogenic roles in cancer. We assessed the correlations between the expression and mutations of HIF1A and ARID1A in histopathologically confirmed pituitary adenomas. METHODS: We performed a retrospective analysis of 71 patients who had undergone surgery for pituitary adenoma. Patient demographic, radiological, and histopathological features were correlated with HIF1A and ARID1A expression. RESULTS: Most cases were HIF1A positive (62%). No significant correlation was found between HIF1A expression and age, gender, tumor size, bone erosion, hemorrhage, or Ki-67 index. An inverse correlation was demonstrated between HIF1A and cavernous sinus invasion (P = 0.035). ARID1A loss was found in 28.2% of pituitary adenomas. No significant correlation was found between ARID1A and any of the assessed variables. CONCLUSIONS: In our patient cohort, we found that most pituitary adenomas expressed HIF1A. To the best of our knowledge, we are the first to assess the presence of ARID1A loss in pituitary adenomas, which occurred in 28.2% of cases. No individual demographic, imaging, or histopathological feature was predictive of ARID1A. Likewise, with the exception of an increased incidence of cavernous sinus invasion, no correlation was found with HIF1A. Given the prognostic value of these markers in other malignancies, their frequency in pituitary adenomas warrants further exploration of their potential role in pituitary adenoma treatment and outcome.en_US
dc.identifier.doi10.1016/j.wneu.2018.09.196en_US
dc.identifier.endpageE722en_US
dc.identifier.issn1878-8750
dc.identifier.issn1878-8769
dc.identifier.pmid30292665en_US
dc.identifier.startpageE716en_US
dc.identifier.urihttps://doi.org/10.1016/j.wneu.2018.09.196
dc.identifier.urihttps://hdl.handle.net/11454/29618
dc.identifier.volume121en_US
dc.identifier.wosWOS:000452897000088en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofWorld Neurosurgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectARID1Aen_US
dc.subjectHypoxia-inducible factor 1en_US
dc.subjectalpha-subuniten_US
dc.subjectImmunohistochemistryen_US
dc.subjectPituitary adenomaen_US
dc.titleHypoxia-Inducible Factor 1 alpha and AT-Rich Interactive Domain-Containing Protein 1A Expression in Pituitary Adenomas: Association with Pathological, Clinical, and Radiological Featuresen_US
dc.typeArticleen_US

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