Zostera noltii extract lowers blood glucose and restores vascular function in diabetic rats

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dc.contributor.authorHaznedaroglu, Mehmet Zeki
dc.contributor.authorGokce, Goksel
dc.date.accessioned2019-10-27T22:05:41Z
dc.date.available2019-10-27T22:05:41Z
dc.date.issued2014
dc.departmentEge Üniversitesien_US
dc.description.abstractThe antidiabetic effect of seagrass Zostera noltii extract was investigated through a crosstalk between its antioxidant and vasoprotective properties. The extract was orally administered to alloxan-diabetic rats (50, 150, 250 mg/kg body weight). Serum glucose was determined; liver and kidney functions, body weight, total leukocyte counts were measured; liver oxidative markers were assayed. Acetylcholine, phenylephrine and 5-HT responses were tested. eNOS levels and generation of ROS in aortic tissue were quantified. The extract of Z. noltii lowered blood glucose in all tested dose levels. Extract at a concentration of 50 mg/kg failed to preserve the levels of antioxidants and did not alter lipid peroxidation whereas higher doses improved liver oxidative status. Impaired acetylcholine relaxations, augmented phenylephrine and 5-HT contractions in alloxan-diabetic aortic rings were restored by Z. noltii treatment. This recovery was accompanied by increased eNOS synthesis and a reduction in ROS generation. The extract lowers blood glucose and prevents hyperglycemia-induced endothelial dysfunction in alloxan-diabetic rats.en_US
dc.description.sponsorshipEge UniversityEge University [06/ECZ/003]en_US
dc.description.sponsorshipThis work was carried out in laboratories of Department of Pharmaceutical Botany and Department of Pharmacology (Ege University, Faculty of Pharmacy). Authors thank Prof. Ulvi Zeybek and Prof. Levent Ustunes for their kind supports. This study was supported by Ege University Project Fund 06/ECZ/003.en_US
dc.identifier.doi10.3329/bjp.v9i3.19437
dc.identifier.endpage397en_US
dc.identifier.issn1991-007X
dc.identifier.issn1991-0088
dc.identifier.issn1991-007Xen_US
dc.identifier.issn1991-0088en_US
dc.identifier.issue3en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage389en_US
dc.identifier.urihttps://doi.org/10.3329/bjp.v9i3.19437
dc.identifier.urihttps://hdl.handle.net/11454/48555
dc.identifier.volume9en_US
dc.identifier.wosWOS:000343126700024en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherBangladesh Pharmacological Socen_US
dc.relation.ispartofBangladesh Journal of Pharmacologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAntioxidanten_US
dc.subjectDiabetesen_US
dc.subjectEndothelial dysfunctionen_US
dc.subjectZostera noltiien_US
dc.titleZostera noltii extract lowers blood glucose and restores vascular function in diabetic ratsen_US
dc.typeArticleen_US

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