Design of Polymeric Surfaces as Platforms for Streamlined Cancer Diagnostics in Liquid Biopsies

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dc.authorscopusid57199103659
dc.authorscopusid57188963997
dc.authorscopusid57564391200
dc.authorscopusid6602258835
dc.authorscopusid57205630119
dc.authorscopusid6507577336
dc.authorscopusid8429335700
dc.contributor.authorGhorbanizamani, Faezeh
dc.contributor.authorMoulahoum, Hichem
dc.contributor.authorCelik, Emine Guler
dc.contributor.authorZihnioglu, Figen
dc.contributor.authorBeduk, Tutku
dc.contributor.authorGoksel, Tuncay
dc.contributor.authorTurhan, Kutsal
dc.date.accessioned2024-08-25T18:53:04Z
dc.date.available2024-08-25T18:53:04Z
dc.date.issued2023
dc.departmentEge Üniversitesien_US
dc.description.abstractMinimally invasive approaches for cancer diagnosis are an integral step in the quest to improve cancer survival. Liquid biopsies such as blood samples are matrices explored to extract valuable information about the tumor and its state through various indicators, such as proteins, peptides, tumor DNA, or circulating tumor cells. Although these markers are scarce, making their isolation and detection in complex matrices challenging, the development in polymer chemistry producing interesting structures, including molecularly imprinted polymers, branched polymers, nanopolymer composites, and hybrids, allowed the development of enhanced platforms with impressive performance for liquid biopsies analysis. This review describes the latest advances and developments in polymer synthesis and their application for minimally invasive cancer diagnosis. The polymer structures improve the operational performances of biosensors through various processes, such as increased affinity for enhanced sensitivity, improved binding, and avoidance of non-specific interactions for enhanced specificity. Furthermore, polymer-based materials can be a tremendous help in signal amplification of usually low-concentrated targets in the sample. The pros and cons of these materials, how the synthesis process affects their performance, and the device applications for liquid biopsies diagnosis will be critically reviewed to show the essentiality of this technology in oncology and clinical biomedicine.en_US
dc.identifier.doi10.3390/bios13030400
dc.identifier.issn2079-6374
dc.identifier.issue3en_US
dc.identifier.pmid36979612en_US
dc.identifier.scopus2-s2.0-85151109418en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.3390/bios13030400
dc.identifier.urihttps://hdl.handle.net/11454/102964
dc.identifier.volume13en_US
dc.identifier.wosWOS:000954214000001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMDPIen_US
dc.relation.ispartofBiosensors-Baselen_US
dc.relation.publicationcategoryDiğeren_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz20240825_Gen_US
dc.subjectliquid biopsyen_US
dc.subjectbiosensoren_US
dc.subjectpolymersen_US
dc.subjectcanceren_US
dc.subjectoncologyen_US
dc.subjectdiagnosisen_US
dc.subjectCirculating Tumor-Cellsen_US
dc.subjectLabel-Freeen_US
dc.subjectElectrochemical Detectionen_US
dc.subjectMultivalent Bindingen_US
dc.subjectEfficient Captureen_US
dc.subjectPeripheral-Blooden_US
dc.subjectBreast-Canceren_US
dc.subjectDnaen_US
dc.subjectBiosensoren_US
dc.subjectGolden_US
dc.titleDesign of Polymeric Surfaces as Platforms for Streamlined Cancer Diagnostics in Liquid Biopsiesen_US
dc.typeReview Articleen_US

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