Effect of fish-oil enriched diet on leukotriene level in experimental trinitrobenzen sulfonic acid (TNB) colitis in rats [Deneysel trinitrobenzensulfonik asit (TNB) kolitinde balik yagindan zengin diyetin lokotrien duzeylerine etkisi]

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dc.contributor.authorYuceyar H.
dc.contributor.authorOzutemiz O.
dc.contributor.authorHuseyinov A.
dc.contributor.authorAlkanat M.
dc.contributor.authorBor S.
dc.contributor.authorCoker I.
dc.contributor.authorBatur Y.
dc.date.accessioned2019-10-27T00:32:28Z
dc.date.available2019-10-27T00:32:28Z
dc.date.issued1997
dc.departmentEge Üniversitesien_US
dc.description.abstractThe etiology of inflammatory bowel disease (IBD) is still unknown and the treatment of recurrences of IBD is also inadequate. In this study, we investigated the protective role of a fish oil (FO) - enriched diet in a rat model of TNP colitis. 20 male Wistar-Albino rats were randomized into 2 groups (n = 10). All of them were fed for 6 weeks with a standard diet (group-1) and standard diet plus FO (% 8) (group-2). At the end of this period, TNP (30 mg in 0,25 ml of % 30 ethanol) were intrarectally administered. After two weeks, the rats were sacrificed and the distal colon was removed. The Specimens were histopathologically evaluated. The MPO enzyme activities were measured and leukotriene B4 (LTB4) and LTC4 levels were determined by radioimmunoassay. MPO activities, LTB4 and LTC4 levels were (respectively) 30,41 ± 1,94 Ug/wet weight, 372,1 ± 65,24 pg/mg tissue protein, 450,0 ± 56,45 pg/mg tissue protein. These levels were reduced in group-2 (respectively) 2,43 ± 0,47 Ug/wet weight, 34,5 ± 8,16 and 64,0 ± 10,46 pg/mg tissue protein. There were significant differences in MPO activities, LTB4 and LTC4 levels and histopathological scores between the two groups (respectively p = 0,0108, p = 0,0034, p = 0,0024, p = 0,002). In conclusion, FO-enriched diet could reduce the colon damage in TNP colitis in rats.en_US
dc.identifier.endpage231en_US
dc.identifier.issn1300-4948
dc.identifier.issn1300-4948en_US
dc.identifier.issue2en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage226en_US
dc.identifier.urihttps://hdl.handle.net/11454/23794
dc.identifier.volume8en_US
dc.indekslendigikaynakScopusen_US
dc.language.isotren_US
dc.relation.ispartofTurkish Journal of Gastroenterologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectfish oilen_US
dc.subjectLTB4en_US
dc.subjectLTC4en_US
dc.subjectTNB colitisen_US
dc.titleEffect of fish-oil enriched diet on leukotriene level in experimental trinitrobenzen sulfonic acid (TNB) colitis in rats [Deneysel trinitrobenzensulfonik asit (TNB) kolitinde balik yagindan zengin diyetin lokotrien duzeylerine etkisi]en_US
dc.typeArticleen_US

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