Evaluation of skin permeation and anti-inflammatory and analgesic effects of new naproxen microemulsion formulations

Basit Öğe Kaydı
dc.contributor.authorOkur, Neslihan Ustundag
dc.contributor.authorApaydin, Sebnem
dc.contributor.authorYavasoglu, N. Ulku Karabay
dc.contributor.authorYavasoglu, Altug
dc.contributor.authorKarasulu, H. Yesim
dc.date.accessioned2019-10-27T21:36:16Z
dc.date.available2019-10-27T21:36:16Z
dc.date.issued2011
dc.departmentEge Üniversitesien_US
dc.description.abstractThe aim of this study was to evaluate the potential application of microemulsions as a transdermal drug delivery for naproxen (Np). The pseudo-ternary phase diagrams were developed for microemulsions composed of isopropyl myristate, Span 80, Labrafll M, Labrasol, and Cremophor EL, ethanol and isopropyl alcohol and 0.5 N sodium hydroxide. The final concentration of Np in microemulsion systems was 10% (w/w). The microemulsions were characterised by conductivity, droplet size, viscosity and pH. Moreover, in vitro permeability studies were performed using diffusion cells from rat skin. The permeation rates of Np from microemulsions (M1(Np) and M2(Np)) were higher than the commercial (C) gel formulation. The paw oedema test was performed in rats to evaluate the anti-inflammatory activity of Np. The volume increase in paw oedema after 6 hr was 0.71 +/- 0.46% with M2(Np), whereas M1(Np) and C exhibited 6.48 +/- 2.71% and 14.97 +/- 3.15% increases in oedema, respectively. Additionally, a significant analgesic effect was detected in the hot plate and tail-flick tests for all test microemulsion and C formulations when compared with the control. Histopathological examination of the treated skin was performed to investigate changes in skin morphology. In conclusion, the microemulsion formulations, especially the M2(Np) formulation, may be used as an effective alternative for the transdermal delivery of Np. Crown Copyright (C) 2011 Published by Elsevier B.V. All rights reserved.en_US
dc.description.sponsorshipUniversity of Ege, Faculty of Pharmacy, and Department of Pharmaceutical TechnologyEge University [08/ECZ/006]en_US
dc.description.sponsorshipThis study was supported by University of Ege, Faculty of Pharmacy, and Department of Pharmaceutical Technology (08/ECZ/006).en_US
dc.identifier.doi10.1016/j.ijpharm.2011.06.026en_US
dc.identifier.endpage144en_US
dc.identifier.issn0378-5173
dc.identifier.issue1en_US
dc.identifier.pmid21723930en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage136en_US
dc.identifier.urihttps://doi.org/10.1016/j.ijpharm.2011.06.026
dc.identifier.urihttps://hdl.handle.net/11454/46025
dc.identifier.volume416en_US
dc.identifier.wosWOS:000294790800018en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Bven_US
dc.relation.ispartofInternational Journal of Pharmaceuticsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectNaproxenen_US
dc.subjectMicroemulsionen_US
dc.subjectAnti-inflammatoryen_US
dc.subjectAnalgesic effecten_US
dc.subjectHistopathologyen_US
dc.titleEvaluation of skin permeation and anti-inflammatory and analgesic effects of new naproxen microemulsion formulationsen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu