Evaluation of anticoagulant system in Turkish children with Perthes disease

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dc.contributor.authorYilmaz D.
dc.contributor.authorKarapinar L.
dc.contributor.authorKarapinar B.
dc.contributor.authorOzturk H.
dc.contributor.authorKavakli K.
dc.date.accessioned2019-10-27T00:11:19Z
dc.date.available2019-10-27T00:11:19Z
dc.date.issued2005
dc.departmentEge Üniversitesien_US
dc.description.abstractBackground: Perthes Disease (PD) is generally a self-limiting disease of childhood but it causes severe pain and may lead to deformity of the femoral head. Intravascular thrombosis seems to form the main mechanism in the pathogenesis of the disease. The aim of this study was to determine hereditary thrombotic risk factors in Turkish children with PD. Methods: In 46 Perthes patients (35 male, 11 female), family history of thrombotic events was investigated, Protein C (PC), free-Protein S (f-PS), antithrombin (AT) activities, fibrinogen level, and resistance to activated Protein C (APC) were measured. The results were compared with a healthy control group of 79 children matched by age and sex. The relationship between the severity of disease and coagulation system abnormalities was evaluated. Results: While the mean PC and AT activities were significantly lower in the patients than those of the controls, the proprotions of patients with low AT activity, resistance to APC, and a history of hereditary thrombophilia were significantly higher than those of the controls. No difference was observed in coagulation system disorders relative to severity of the disease and bilateral or unilateral disease involvement. Conclusions: This study shows that a possible association between PD and inherited hypercoagulability. Determination of thrombotic risk factors in these patients may bring a new approach to the treatment. Most importantly, this may be a stimulant to take precautions for other thrombotic events, which patients may face later in life.en_US
dc.identifier.doi10.1111/j.1442-200x.2004.01995.xen_US
dc.identifier.endpage48en_US
dc.identifier.issn1328-8067
dc.identifier.issue1en_US
dc.identifier.pmid15693865en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage43en_US
dc.identifier.urihttps://doi.org/10.1111/j.1442-200x.2004.01995.x
dc.identifier.urihttps://hdl.handle.net/11454/22154
dc.identifier.volume47en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofPediatrics Internationalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHereditary thrombophiliaen_US
dc.subjectNatural anticoagulantsen_US
dc.subjectPerthes diseaseen_US
dc.titleEvaluation of anticoagulant system in Turkish children with Perthes diseaseen_US
dc.typeArticleen_US

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