Effect of oxytocin treatment on explant size, plasma and peritoneal levels of MCP-1, VEGF, TNF-alpha and histopathological parameters in a rat endometriosis model

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dc.contributor.authorYeniel, Ahmet Ozgur
dc.contributor.authorErbas, Oytun
dc.contributor.authorErgenoglu, Ahmet Mete
dc.contributor.authorAktug, Huseyin
dc.contributor.authorTaskiran, Dilek
dc.contributor.authorYildirim, Nuri
dc.contributor.authorUlukus, Murat
dc.date.accessioned2019-10-27T22:15:41Z
dc.date.available2019-10-27T22:15:41Z
dc.date.issued2014
dc.departmentEge Üniversitesien_US
dc.description.abstractObjective: To determine the effects of oxytocin (OT) on surgically induced endometriosis in a rat model. Study design: Twelve female Sprague-Dawley rats were included. After the implantation and establishment of autologous endometrium onto the abdominal wall peritoneum, the rats were randomly divided into two groups, treated with intramuscular oxytocin (OT group, 160 mu g kg/day, n = 6) or isotonic NaCl solution (control group, 1 mL kg/day, n = 6) for 28 days. To evaluate the therapeutic effects of OT, the explant volumes were calculated and the levels of vascular endothelial growth factor (VEGF), monocyte chemotactic protein-1, and TNF-alpha were measured in plasma and peritoneal fluid. Endometriotic explants were examined histologically by semiquantitative analysis. Results: After treatment, the mean endometriotic explant volume was decreased in the OT group (p = 0.016). The histopathological score and VEGF immunoexpression of endometriotic explants were significantly lower in the OT group (p = 0.007) than in controls (p = 0.000). Inflammatory cytokine levels in plasma and peritoneal fluid were considerably decreased in the OT group. Moreover, TUNEL immunohistochemistry clearly demonstrated more apoptotic changes in the mononuclear cells of the OT group compared with controls. Conclusion: We suggest that oxytocin might be considered as a potential candidate therapeutic agent for endometriosis. (C) 2014 Elsevier Ireland Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.ejogrb.2013.12.034en_US
dc.identifier.endpage139en_US
dc.identifier.issn0301-2115
dc.identifier.issn1872-7654
dc.identifier.pmid24447470en_US
dc.identifier.startpage134en_US
dc.identifier.urihttps://doi.org/10.1016/j.ejogrb.2013.12.034
dc.identifier.urihttps://hdl.handle.net/11454/50207
dc.identifier.volume175en_US
dc.identifier.wosWOS:000335432000024en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofEuropean Journal of Obstetrics & Gynecology and Reproductive Biologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectOxytocinen_US
dc.subjectEndometriosisen_US
dc.subjectRat modelen_US
dc.subjectVEGFen_US
dc.subjectMCP-1en_US
dc.subjectTNF-alphaen_US
dc.titleEffect of oxytocin treatment on explant size, plasma and peritoneal levels of MCP-1, VEGF, TNF-alpha and histopathological parameters in a rat endometriosis modelen_US
dc.typeArticleen_US

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