3D-speckle tracking echocardiography for assessment of coronary artery disease severity in stable angina pectoris

dc.contributor.authorDogdus, Mustafa
dc.contributor.authorSimsek, Evrim
dc.contributor.authorCinar, Cahide Soydas
dc.date.accessioned2019-10-27T09:46:24Z
dc.date.available2019-10-27T09:46:24Z
dc.date.issued2019
dc.departmentEge Üniversitesien_US
dc.description.abstractBackground and Aim: Stable angina pectoris is a common disease that may cause disability. Some noninvasive new methods can be useful for the detection of early stage coronary artery disease. The relationship between coronary artery disease (CAD) severity and resting 3-dimensional-speckle tracking echocardiography (3D-STE) in stable angina pectoris patients was evaluated in this study. Methods: One hundred and twenty consecutive patients between 18-80 years of age and without a history of CAD to whom elective coronary angiography was planned after positive stress test or myocardial perfusion scintigraphy were enrolled in the study. 3D-STE was performed and global longitudinal strain (GLS), global circumferential strain (GCS), global radial strain (GRS), and global area strain (GAS) were measured before coronary angiography. A Gensini score of >= 20 was accepted as critical CAD. Correlation between Gensini scores and 3D-STE results were evaluated. Results: Mean age was 60.7 +/- 10.01 years, and 55% of the patient population were male. There were not any significant differences between critical CAD and noncritical CAD groups for age, gender, history of hypertension, diabetes mellitus, hyperlipidemia, and Left Ventricular Ejection Fraction. Mean GLS was-12, GCS was-18.8, GRS was 33.4, GAS was-28.9, and mean Gensini score was 18.8. GLS and all other strain parameters were significantly worse in patients with critical CAD group compared with noncritical CAD group and also positive linear correlation was observed between Gensini score and all measured strain parameters (r = 0.568, P < 0.001 for Gensini score and GLS; r = 0.617, P < 0.001 for Gensini score and GAS). A GLS value of >-10 has 88.9% sensitivity and 92.9% specificity; A GAS value of >-21 has 97.2% sensitivity and 88.1% specificity to detect critical CAD. Conclusions: 3D-STE is a noninvasive and handy parameter to detect subclinical left ventricular dysfunction and global strain values were significantly correlated with CAD severity. GAS has the sensitivity of 97.2% and specificity of 88.1% to detect critical CAD. Adding 3D strain echocardiography to exercise test or myocardial perfusion scintigraphy might increase sensitivity to detect critical CAD in clinical practice.en_US
dc.identifier.doi10.1111/echo.14214en_US
dc.identifier.endpage327en_US
dc.identifier.issn0742-2822
dc.identifier.issn1540-8175
dc.identifier.issue2en_US
dc.identifier.pmid30515893en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage320en_US
dc.identifier.urihttps://doi.org/10.1111/echo.14214
dc.identifier.urihttps://hdl.handle.net/11454/29271
dc.identifier.volume36en_US
dc.identifier.wosWOS:000458874600015en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofEchocardiography-A Journal of Cardiovascular Ultrasound and Allied Techniquesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject3D-speckle tracking echocardiographyen_US
dc.subjectGensini scoreen_US
dc.subjectstable angina pectorisen_US
dc.title3D-speckle tracking echocardiography for assessment of coronary artery disease severity in stable angina pectorisen_US
dc.typeArticleen_US

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