Cardiac Assessment in Children with MIS-C: Late Magnetic Resonance Imaging Features

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dc.authoridGüner Özenen, Gizem/0000-0002-9725-7501
dc.authorscopusid57414445400
dc.authorscopusid38061964200
dc.authorscopusid23993736300
dc.authorscopusid57221502271
dc.authorscopusid57222327020
dc.authorscopusid6602578908
dc.authorscopusid57191622889
dc.authorwosidGüner Özenen, Gizem/ABG-2316-2021
dc.authorwosidYazıcı Özkaya, Pınar/GWQ-8519-2022
dc.contributor.authorArslan, Sema Yildirim
dc.contributor.authorBal, Zumrut Sahbudak
dc.contributor.authorBayraktaroglu, Selen
dc.contributor.authorOzenen, Gizem Guner
dc.contributor.authorBilen, Nimet Melis
dc.contributor.authorLevent, Erturk
dc.contributor.authorAy, Oguzhan
dc.date.accessioned2023-01-12T19:50:04Z
dc.date.available2023-01-12T19:50:04Z
dc.date.issued2022
dc.departmentN/A/Departmenten_US
dc.description.abstractMultisystem Inflammatory Syndrome (MIS-C) is a new entity that emerges 2-4 weeks after the SARS-CoV-2 infection in children. MIS-C can affect all systems, the most severe of which is cardiac involvement. The duration of the cardiac symptoms is still uncertain and may be persistent or prolonged. The American College of Rheumatology Clinical Guidelines recommends cardiac magnetic resonance imaging (MRI) 2-6 months after the diagnosis of MIS-C in patients presenting with significant transient left ventricular (LV) dysfunction in the acute phase of illness (LV ejection fraction 50%) or persistent LV dysfunction. There are a few studies investigating cardiac MRI findings in MIS-C patients. In this study, we aimed to evaluate cardiac MRI findings, at the earliest 3 months after diagnosis, and compare these findings with the echocardiograms in children with MIS-C. A retrospective study including 34 MIS-C patients was conducted at a tertiary-level University Hospital between June 2020 and July 2021. Centers for Disease Control and Prevention criteria were used in the diagnosis of MIS-C. Cardiac MRI was performed at least 3 months after MIS-C diagnosis. The study included 17 (50%) boys and 17 (50%) girls with a mean age of 9.31 +/- 4.72 years. Initial echocardiographic evaluation revealed cardiac abnormality in 13 (38.2) patients; 4 (11.8%) pericardial effusion, 4 (11.8%) left ventricular ejection fraction (LVEF) < 55%, and 5 (14.7%) coronary artery dilatation. Echocardiography showed normal LV systolic function in all patients during follow-up; coronary dilatation persisted in 2 of 5 (40%) patients at the 6th-month visit. Cardiac MRI was performed in 31 (91.2%) patients, and myocardial hyperemia was not detected in any patients (T1 relaxation time was < 1044 ms in all children). However, 9 (29%) patients' MRI showed isolated elevated T2 levels, and 19 (61.3%) revealed at least one of the following findings: pericardial effusion, right ventricular dysfunction, or LVEF abnormality. In patients with MIS-C, a high rate of cardiac involvement, particularly pericardial effusion was determined by cardiac MRI performed at the earliest 2-6 months after diagnosis. Even if echocardiography does not reveal any abnormality in the initial phase, cardiac MRI should be suggested in MIS-C patients in the late period. This is the first study reporting cardiac MRI findings in the late period of MIS-C patients.en_US
dc.identifier.doi10.1007/s00246-022-02977-y
dc.identifier.issn0172-0643
dc.identifier.issn1432-1971
dc.identifier.pmid35916926en_US
dc.identifier.scopus2-s2.0-85135329351en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1007/s00246-022-02977-y
dc.identifier.urihttps://hdl.handle.net/11454/76007
dc.identifier.wosWOS:000835156500001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofPediatric Cardiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectMIS-Cen_US
dc.subjectCardiac MRIen_US
dc.subjectEchocardiographyen_US
dc.subjectMultisystem Inflammatory Syndromeen_US
dc.subjectSars-Cov-2en_US
dc.subjectDiseaseen_US
dc.subjectCovid-19en_US
dc.subjectHearten_US
dc.titleCardiac Assessment in Children with MIS-C: Late Magnetic Resonance Imaging Featuresen_US
dc.typeArticleen_US

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