Relationship Between Serum Macrophage Migration Inhibitory Factor Level and Insulin Resistance, High-Sensitivity C-Reactive Protein and Visceral Fat Mass in Prediabetes

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dc.contributor.authorBilgir, Oktay
dc.contributor.authorGokcen, Belma
dc.contributor.authorBilgir, Ferda
dc.contributor.authorGuler, Asli
dc.contributor.authorCalan, Mehmet
dc.contributor.authorYuksel, Arif
dc.contributor.authorAslanipour, Behnaz
dc.contributor.authorAksit, Murat
dc.contributor.authorBozkaya, Giray
dc.date.accessioned2019-10-27T10:46:57Z
dc.date.available2019-10-27T10:46:57Z
dc.date.issued2018
dc.departmentEge Üniversitesien_US
dc.description.abstractBackground: Growing evidence suggest that macrophage migration inhibitory factor (MIF) plays a vital role in glucose metabolism. We aimed to ascertain whether MIF levels are altered in subjects with prediabetes and also to determine the relationship between MIF and metabolic parameters as well as visceral fat mass. Material and Methods: This cross-sectional study included 40 subjects with prediabetes and 40 age-, body mass index (BMI)- and sex-matched subjects with normal glucose tolerance. Circulating MIF levels were measured using enzyme-linked immunosorbent assay. Metabolic parameters of recruited subjects were evaluated. Visceral fat mass was measured using bioelectrical impedance method. Results: Circulating MIF levels were found to be elevated in subjects with prediabetes compared to controls (26.46 +/- 16.98 versus 17.44 +/- 11.80 ng/mL, P = 0.007). MIF positively correlated with BMI, visceral fat mass and indirect indices of homeostasis model assessment of insulin resistance. In linear regression model, an independent association was found between MIF levels and metabolic parameters, including BMI, visceral fat mass and homeostasis model assessment of insulin resistance. Multivariate logistic regression analyses revealed that the odds ratio for prediabetes was higher in subjects in the highest quartile of MIF compared to those in the lowest quartile, after adjusting for potential confounders. Conclusions: Increased MIF levels are associated with the elevation of prediabetic risk.en_US
dc.identifier.doi10.1016/j.amjms.2017.10.006en_US
dc.identifier.endpage43en_US
dc.identifier.issn0002-9629
dc.identifier.issn1538-2990
dc.identifier.issue1en_US
dc.identifier.pmid29289260en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage37en_US
dc.identifier.urihttps://doi.org/10.1016/j.amjms.2017.10.006
dc.identifier.urihttps://hdl.handle.net/11454/31362
dc.identifier.volume355en_US
dc.identifier.wosWOS:000418892100008en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofAmerican Journal of the Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPrediabetesen_US
dc.subjectMIFen_US
dc.subjectInsulin resistanceen_US
dc.titleRelationship Between Serum Macrophage Migration Inhibitory Factor Level and Insulin Resistance, High-Sensitivity C-Reactive Protein and Visceral Fat Mass in Prediabetesen_US
dc.typeArticleen_US

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