Role of total antioxidant capacity and oxidative stress in fertilization and embryo selection in the IVF cycle

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dc.authoridSozmen, Eser Y./0000-0002-6383-6724
dc.authorwosidSozmen, Eser Y./ABI-5243-2020
dc.contributor.authorSeyfettinoglu, Sevtap
dc.contributor.authorSahin, Gulnaz
dc.contributor.authorAkdogan, Aysin
dc.contributor.authorGoker, Ege Nazan Tavmergen
dc.contributor.authorAkcay, Yasemin
dc.contributor.authorSozmen, Eser Y.
dc.contributor.authorTavmergen, Erol
dc.date.accessioned2023-01-12T20:11:25Z
dc.date.available2023-01-12T20:11:25Z
dc.date.issued2021
dc.departmentN/A/Departmenten_US
dc.description.abstractPurpose: This study aims to evaluate the oxidant and antioxidant parameters in follicular fluid and embryo culture medium in IVF cycles and investigate their effects on embryo quality, fertilization success, and pregnancy. Materials and Methods: Fifty-one patients who underwent IVF/ICSI were included in this prospective study. Two hundred sixty of a total of 454 follicular fluids and the cell culture media of transferred fifty-one embryos (one from each patient) were examined. Antioxidant activity (AOA), Trolox equivalent antioxidant capacity (TEAC), thiobarbiturate reactive substances (TBARS), ferric antioxidant power (FRAP), paraoxonase, nitrotyrosine were analyzed. Results: TBARS were significantly lower in the follicular fluid of fertilized oocytes than in non-fertilized oocytes (21 vs. 29.75 nmol/ml). There was no difference in terms of other parameters. TEAC levels were higher in oocytes in the agonist protocol group than in the antagonist protocol group. In terms of embryo quality, there were no differences between the groups in any analysis. TEAC levels were higher in the embryo cell culture medium in the group that became pregnant after embryo transfer on the second day. Conclusion: When oxidative stress and antioxidant parameters were evaluated in both follicle fluid and embryo cell culture medium, it was determined that lipid peroxidation negatively affected fertilization. However, there is no significant difference in terms of embryo quality and pregnancy rates.en_US
dc.identifier.doi10.17826/cumj.979955
dc.identifier.endpage1701en_US
dc.identifier.issn2602-3032
dc.identifier.issn2602-3040
dc.identifier.issue4en_US
dc.identifier.startpage1694en_US
dc.identifier.trdizinid468342en_US
dc.identifier.urihttps://doi.org/10.17826/cumj.979955
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/468342
dc.identifier.urihttps://hdl.handle.net/11454/78109
dc.identifier.volume46en_US
dc.identifier.wosWOS:000728748600046en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherCukurova Univ, Fac Medicineen_US
dc.relation.ispartofCukurova Medical Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectIVFen_US
dc.subjectoxidative stressen_US
dc.subjectfertilizationen_US
dc.subjectembryo qualityen_US
dc.subjectControlled Ovarian Hyperstimulationen_US
dc.subjectEndothelial Growth-Factoren_US
dc.subjectHuman Follicular-Fluiden_US
dc.subjectNitric-Oxideen_US
dc.subjectPreimplantation Embryoen_US
dc.subjectCulture-Mediumen_US
dc.subjectSupplementationen_US
dc.subjectQualityen_US
dc.subjectParaoxonase-1en_US
dc.subjectApoptosisen_US
dc.titleRole of total antioxidant capacity and oxidative stress in fertilization and embryo selection in the IVF cycleen_US
dc.typeArticleen_US

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