The effect of 8-week different-intensity walking exercises on serum hepcidin, IL-6, and iron metabolism in pre-menopausal women

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dc.contributor.authorBuyukyazi, G.
dc.contributor.authorUlman, C.
dc.contributor.authorCelik, A.
dc.contributor.authorCetinkaya, C.
dc.contributor.authorSisman, A. R.
dc.contributor.authorCimrin, D.
dc.contributor.authorDogru, Y.
dc.contributor.authorKaya, D.
dc.date.accessioned2019-10-27T11:09:45Z
dc.date.available2019-10-27T11:09:45Z
dc.date.issued2017
dc.departmentEge Üniversitesien_US
dc.description.abstractObjective: Hepcidin may be an important mediator in exercise-induced iron deficiency. Despite the studies investigating acute exercise effects on hepcidin and markers of iron metabolism, we found no studies examining the chronic effects of walking exercises (WE) on hepcidin and markers of iron metabolism in premenopausal women. The chronic effects of two 8-week different-intensity WE on hepcidin, interleukin 6 (IL-6), and markers of iron metabolism in pre-menopausal women were examined. Methods: Exercise groups (EG) [moderate tempo walking group (MTWG), n = 11; brisk walking group (BWG), n = 11] walked 3 days/week, starting from 30 to 51 min. Control group (CG; n = 8) did not perform any exercises. BWG walked at similar to 70%-75%; MTWG at similar to 50%-55% of HRRmax. VO2max, hepcidin, IL-6, and iron metabolism markers were determined before and after the intervention. Results: VO2max increased in both EGs, favoring the BWG. Hepcidin increased in the BWG (p < 0.01) and CG (p < 0.05). IL-6 decreased in the BWG and the MTWG (p < 0.05; p < 0.01). While iron, ferritin, transferrin, and transferrin saturation levels did not change in any group, total iron binding capacity (p < 0.05), red blood cells (p < 0.05), and hematocrit (p < 0.01) increased only in the BWG. Conclusion: Both WE types may be useful to prevent inflammation. However, brisk walking is advisable due to the positive changes in VO2max and some iron metabolism parameters, which may contribute to prevent iron deficiency. The increase in hepcidin levels remains unclear and necessitates further studies.en_US
dc.identifier.doi10.1556/2060.104.2017.1.7en_US
dc.identifier.endpage63en_US
dc.identifier.issn2498-602X
dc.identifier.issue1en_US
dc.identifier.pmid28361576en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage52en_US
dc.identifier.urihttps://doi.org/10.1556/2060.104.2017.1.7
dc.identifier.urihttps://hdl.handle.net/11454/32321
dc.identifier.volume104en_US
dc.identifier.wosWOS:000402086800006en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAkademiai Kiado Rten_US
dc.relation.ispartofPhysiology Internationalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjecthepcidinen_US
dc.subjectIL-6en_US
dc.subjectiron metabolismen_US
dc.subjectpre-menopausal womenen_US
dc.subjectwalkingen_US
dc.titleThe effect of 8-week different-intensity walking exercises on serum hepcidin, IL-6, and iron metabolism in pre-menopausal womenen_US
dc.typeArticleen_US

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