Alkaloid profiling of Galanthus woronowii Losinsk. by GC-MS and evaluation of its biological activity

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dc.contributor.authorBozkurt, Buket
dc.contributor.authorEmir, Ahmet
dc.contributor.authorKaya, Gulen Irem
dc.contributor.authorOnur, Mustafa Ali
dc.contributor.authorBerkov, Strahil
dc.contributor.authorBastida, Jaume
dc.contributor.authorUnver Somer, Nehir
dc.date.accessioned2019-10-27T11:19:21Z
dc.date.available2019-10-27T11:19:21Z
dc.date.issued2017
dc.departmentEge Üniversitesien_US
dc.description.abstractThe alkaloid profiles of the aerial parts and the bulbs of Galanthus woronowii Losinsk. were analyzed by means of Gas Chromatography-Mass Spectrometry (GC-MS). Totally, twenty-eight compounds were detected. Galanthamine and galanthine were found to be the main alkaloids both in the extracts of the aerial parts and the bulbs. Most of the identified compounds were lycorine and galanthamine-type Amaryllidaceae alkaloids. In addition, the acetylcholinesterase (AChE) inhibitor potentials of the extracts prepared from the aerial parts and bulbs were determined by in vitro Ellman's method and both of the extracts were found to exhibit significant activity (aerial parts: IC50 = 0.027 mu g/mL and bulbs: IC50 = 0.084 mu g/mL).en_US
dc.description.sponsorshipEge University Research FundEge University [09/ECZ/021, 09/ECZ/018]; TUBITAKTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [104T272]en_US
dc.description.sponsorshipThis study was financially supported by Ege University Research Fund (Project No: 09/ECZ/021 and 09/ECZ/018) and partially supported by TUBITAK (104T272).en_US
dc.identifier.doi10.12991/mpj.2017.12
dc.identifier.endpage920en_US
dc.identifier.issn1309-0801
dc.identifier.issue4en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage915en_US
dc.identifier.urihttps://doi.org/10.12991/mpj.2017.12
dc.identifier.urihttps://hdl.handle.net/11454/32750
dc.identifier.volume21en_US
dc.identifier.wosWOS:000417369600022en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherMarmara Univ, Fac Pharmacyen_US
dc.relation.ispartofMarmara Pharmaceutical Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectGalanthus woronowiien_US
dc.subjectAmaryllidaceaeen_US
dc.subjectGC-MSen_US
dc.subjectalkaloidsen_US
dc.titleAlkaloid profiling of Galanthus woronowii Losinsk. by GC-MS and evaluation of its biological activityen_US
dc.typeArticleen_US

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