Evaluation of I-131-Pentamidine for scintigraphy of experimentally Leishmania tropica-infected hamsters

Basit Öğe Kaydı
dc.contributor.authorInceboz, Tonay
dc.contributor.authorLambrecht, Fatma Yurt
dc.contributor.authorEren, Mine Sencan
dc.contributor.authorGirginkardesler, Nogay
dc.contributor.authorBekis, Recep
dc.contributor.authorYilmaz, Osman
dc.contributor.authorEr, Ozge
dc.contributor.authorOzbilgin, Ahmet
dc.date.accessioned2019-10-27T22:14:45Z
dc.date.available2019-10-27T22:14:45Z
dc.date.issued2014
dc.departmentEge Üniversitesien_US
dc.description.abstractWe aimed to assess the ability of I-131-Pentamidine scintigraphy to detect the lesions of Leishmania tropica infection. An experimental model of cutaneous leishmaniasis was developed. The presence of cutaneous leishmaniasis was confirmed. Pentamidine was radioiodinated with I-131. The radiolabeled pentamidine was validated by the requisite quality control tests to check its radiolabeling efficiency, in vitro stability. I-131-Pentamidine (activity: 18.5 MBq/100 mu l) was injected intracardiacally into infected hamsters. Static whole body images of the hamsters were acquired under the gamma camera at 5 and 30 min, 2, 6 and 24 h following the administration. On the scintigrams, anatomically adjusted regions of interest (ROIs) were drawn over the right feet (target) and left feet (not-target) and various organs. Accumulation of I-131-Pentamidine at sites of infection is expressed as the target to non-target (T/NT) ratio. The results T/NT ratio decreased with time. In concluding the I-131-Pentamidine has poor sensitivity in detection of L. tropica infection.en_US
dc.identifier.doi10.3109/1061186X.2013.878943en_US
dc.identifier.endpage420en_US
dc.identifier.issn1061-186X
dc.identifier.issn1029-2330
dc.identifier.issue5en_US
dc.identifier.pmid24405123en_US
dc.identifier.startpage416en_US
dc.identifier.urihttps://doi.org/10.3109/1061186X.2013.878943
dc.identifier.urihttps://hdl.handle.net/11454/50064
dc.identifier.volume22en_US
dc.identifier.wosWOS:000336500400006en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherInforma Healthcareen_US
dc.relation.ispartofJournal of Drug Targetingen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAmastigoteen_US
dc.subjectI-131-Pentamidine scintigraphyen_US
dc.subjectLeishmania tropicaen_US
dc.subjectLeishmaniasis hamsteren_US
dc.subjectpromastigoteen_US
dc.titleEvaluation of I-131-Pentamidine for scintigraphy of experimentally Leishmania tropica-infected hamstersen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu