Investigation of Human Herpesvirus-8 Seroprevalence in Blood Donors and HIV-Positive Patients Admitted to Ege University Medical School Hospital, Turkey

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dc.contributor.authorAltuglu, Imre
dc.contributor.authorYolcu, Ayfer
dc.contributor.authorOcek, Zeliha Asli
dc.contributor.authorYazan Sertoz, Ruchan
dc.contributor.authorGokengin, Deniz
dc.date.accessioned2019-10-27T22:58:20Z
dc.date.available2019-10-27T22:58:20Z
dc.date.issued2016
dc.departmentEge Üniversitesien_US
dc.description.abstractHuman herpesvirus 8 (HHV-8), classified in Herpesviridae family, is the etiological agent of Kaposi's sarcoma (KS), primary effusion lymphoma and multicentric Castleman's disease. In contrast to the other herpesviruses, HHV-8 seroprevalence is low in general populations; however, the higher prevalence observed in individuals with immunodeficiencies such as AIDS poses an increased risk for KS. The global distribution of HHV-8 shows great variations, with the highest seroprevalence seen in Africa. The number of studies on the seroprevalence of HHV-8 in Turkey are limited. The aim of this study was to determine the HHV-8 seroprevalences in healthy blood donors and HIV-positive patients, that will contribute HHV-8 seroepidemiological data in our country. This study was designed as a cross-sectional study. A total of 551 healthy donors (76 female, 475 male; age range: 18-65 years) admitted to Ege University Medical School Hospital, Blood Center for blood donation between December 2013-January 2014, and 173 HIV-positive patients (30 female, 143 male; age range: 18-65 years) admitted to infectious diseases outpatient clinic between October 2013-January 2014, were included in the study. A commercial ELISA method (KSHV/HHV-8 IgG ELISA Kit, Advanced Biotechnologies Inc, USA) was used for the detection of IgG antibodies that were structured against HHV-8 lytic antigens. In the study, 29 (29/551, 5.3%) of blood donors and 44 (44/173, 25.4%) of HIV-positive patients, with a total of 73 (73/724, 10.1%) cases were found as HHV-8 seropositive. The difference between blood donors and HIV-positive patients in terms of HHV-8 seropositivity rates was statistically significant (5.3% versus 25.4%; p<0.05). In both of the study groups, no statistically significant difference was detected between HHV-8 seropositivity with gender and age. When considering HIV-positive patients, no statistically significant difference was observed between HHV-8 seropositivity with the duration of anti-HIV positivity, CD4(+) T cell count, HIV-RNA status and history of having sexually transmitted disease. As a result, HHV-8 seroprevalence rate detected in our study is similar to the data of other studies performed in Turkey, as well as the rates reported from other European and Asian countries.en_US
dc.identifier.doi10.5578/mb.10751en_US
dc.identifier.endpage111en_US
dc.identifier.issn0374-9096
dc.identifier.issue1en_US
dc.identifier.pmid27058334en_US
dc.identifier.startpage104en_US
dc.identifier.urihttps://doi.org/10.5578/mb.10751
dc.identifier.urihttps://hdl.handle.net/11454/51517
dc.identifier.volume50en_US
dc.identifier.wosWOS:000371499500011en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isotren_US
dc.publisherAnkara Microbiology Socen_US
dc.relation.ispartofMikrobiyoloji Bultenien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectHHV-8en_US
dc.subjectHIV-positive patienten_US
dc.subjectblood donorsen_US
dc.subjectseroprevalenceen_US
dc.titleInvestigation of Human Herpesvirus-8 Seroprevalence in Blood Donors and HIV-Positive Patients Admitted to Ege University Medical School Hospital, Turkeyen_US
dc.typeArticleen_US

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