Does Decompressive Duraplasty Have a Neuroprotective Effect on Spinal Trauma?: An Experimental Study

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dc.contributor.authorCamlar, Mahmut
dc.contributor.authorTurk, Caglar
dc.contributor.authorBuhur, Aylin
dc.contributor.authorOltulu, Fatih
dc.contributor.authorOren, Merve
dc.contributor.authorSenoglu, Mehmet
dc.contributor.authorOzer, Fusun
dc.date.accessioned2019-10-27T09:43:57Z
dc.date.available2019-10-27T09:43:57Z
dc.date.issued2019
dc.departmentEge Üniversitesien_US
dc.description.abstractBACKGROUND: Spinal cord injury (SCI) may result in neuromotor, sensory, and autonomic function damages. Edema because of spinal cord trauma can reach serious dimensions. The aim of this study was to histologically evaluate the effects of duraplasty on neural tissues. METHODS: Twenty-eight Wistar rats were randomly divided into 4 experimental groups: group 1 received laminectomy without SCI (sham); group 2 received laminectomy and SCI with the weight drop method; group 3 received laminectomy, SCI, and duraplasty within the first 6-8 hours of SCI; and group 4 received laminectomy, SCI, and duraplasty after 24 hours of SCI. The neurologic functions of the rats were tested periodically. All animals were euthanized 28 days after the surgery. Histopathologic and immunohistochemical evaluations were performed, and Kruskal-Wallis tests were used for statistical comparison of data between the groups. RESULTS: There was no significant difference in the Tarlov examination scores from different time points between the groups. The number of neurons stained with nuclear factor kappa beta was higher in group 3 than groups 1 and 4. The number of neurons stained with terminal deoxynucleotidyl transferase dUTP nick-end labeling was higher in group 2 than group 3. CONCLUSIONS: Decompressive laminectomy is a procedure frequently used in spinal trauma surgery. However, it is often unclear whether the decompression is fully adequate. Our results will aid the development of further studies regarding the reliability of duraplasty in the treatment of SCI.en_US
dc.identifier.doi10.1016/j.wneu.2019.02.043en_US
dc.identifier.endpageE294en_US
dc.identifier.issn1878-8750
dc.identifier.issn1878-8769
dc.identifier.pmid30822587en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpageE288en_US
dc.identifier.urihttps://doi.org/10.1016/j.wneu.2019.02.043
dc.identifier.urihttps://hdl.handle.net/11454/28938
dc.identifier.volume126en_US
dc.identifier.wosWOS:000469222400035en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofWorld Neurosurgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDuraplastyen_US
dc.subjectExperimenten_US
dc.subjectRaten_US
dc.subjectSpinal traumaen_US
dc.subjectSurgical techniqueen_US
dc.titleDoes Decompressive Duraplasty Have a Neuroprotective Effect on Spinal Trauma?: An Experimental Studyen_US
dc.typeArticleen_US

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