Predictors of outcome in patients with prosthetic valve dysfunction

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dc.contributor.authorIslamoglu, F
dc.contributor.authorIyem, H
dc.contributor.authorApaydin, AZ
dc.contributor.authorOzbaran, M
dc.contributor.authorBuket, S
dc.contributor.authorYuksel, M
dc.contributor.authorTelli, A
dc.contributor.authorDurmaz, I
dc.date.accessioned2019-10-27T18:37:30Z
dc.date.available2019-10-27T18:37:30Z
dc.date.issued2004
dc.departmentEge Üniversitesien_US
dc.description.abstractBackground and aim of the study: The study aim, based on the authors' experience in patients with prosthetic valve dysfunction, was to investigate risk factors for mortality and morbidity by analyzing preoperative, intraoperative and postoperative variables with respect to early and long-term survival. Methods: A retrospective analysis was carried out of 132 patients (47 men, 85 women; mean age 46.8 +/- 12.4 years) who presented for treatment of prosthetic valve dysfunction between December 1992 and February 2003. Two patients received thrombolytic therapy and were excluded from the statistical analysis, which comprised only operatively treated patients; four patients underwent successful surgical repair of mitral mechanical prostheses; all other patients (except two who died perioperatively) underwent prosthetic valve re-replacement (n = 124). Results: Overall mortality and hospital mortality rates were 15.2% and 10.6%, respectively. Postoperatively, 54 complications were seen in 42 patients (32.3%). Preoperative left ventricular endsystolic diameter (LVESD) greater than or equal to45 min and, cardiopulmonary bypass (CPB) time >140 min were independent risk factor's for overall and in-hospital mortality. Female gender, age >60 years and prolonged CPB time were predictors of postoperative complications. The actuarial survival rate was 87.5 +/- 0.3% at five years, and 81.7 +/- 0.4% at 10 years. A reduced left ventricular ejection fraction (LVEF) was the only independent predictor of late death and long-term survival. Conclusion: Preoperative LVESD 45 mm. and lower LVEF were found to be independent predictors of postoperative mortality and late survival, respectively. It is possible to obtain a substantial improvement in outcome and long-term survival if a valvular reoperation can be performed,with shorter CPB time and before left ventricular dysfunction has developed.en_US
dc.identifier.endpage119en_US
dc.identifier.issn0966-8519
dc.identifier.issue1en_US
dc.identifier.pmid14765849en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage109en_US
dc.identifier.urihttps://hdl.handle.net/11454/36421
dc.identifier.volume13en_US
dc.identifier.wosWOS:000188195400023en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherI C R Publishersen_US
dc.relation.ispartofJournal of Heart Valve Diseaseen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titlePredictors of outcome in patients with prosthetic valve dysfunctionen_US
dc.typeArticleen_US

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