Effect of immunotherapy on autoimmune parameters in children with atopic asthma

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dc.contributor.authorTanac, R
dc.contributor.authorDemir, E
dc.contributor.authorAksu, G
dc.contributor.authorSari, G
dc.contributor.authorKutukculer, N
dc.date.accessioned2019-10-27T18:43:34Z
dc.date.available2019-10-27T18:43:34Z
dc.date.issued2002
dc.departmentEge Üniversitesien_US
dc.description.abstractThere is an increased rate of reported autoantibody production in patients with atopic and nonatopic asthma. The possibility of generating autoantibodies after the induction of immunotherapy can be explained by several mechanisms. One of these is immune deviation from TH2 to TH1 response by the effect of immunotherapy in favor of unregulated response to self-antigens. The other theory is a possible antigenic mimicry enabling autoantibody formation in these patients, Sixty-three atopic asthmatic children were included in the study. The patients were divided into three groups: Group 1: patients with atopic bronchial asthma without immunotherapy: Group 11: patients receiving immunotherapy for a maximum of 3 years; Group III: patients receiving immunotherapy for 4-5 years. The autoantibodies examined in the study population were antinuclear antibody, anti-double stranded DNA, rheumatoid factor, liver-kidney microsomal antibody, anti-mitochondrial antibody, anti-thyroglobulin and anti-microsomal antibody, anti-Smith antibody and lupus anticoagulant. An overall incidence of 17.5% autoantibody positivity was observed in patients, with no statistical significance between the treatment groups. IgG levels were significantly elevated in Group III when compared with Group 1. Based on these findings it is suggested, in accordance with other studies, that long-term immunotherapy in the pediatric age group does not cause a significant autoantibody formation other than the overall increased incidence that occurs in asthmatic patients.en_US
dc.identifier.endpage297en_US
dc.identifier.issn0041-4301
dc.identifier.issue4en_US
dc.identifier.pmid12458803en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage294en_US
dc.identifier.urihttps://hdl.handle.net/11454/37229
dc.identifier.volume44en_US
dc.identifier.wosWOS:000179136500004en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTurkish J Pediatricsen_US
dc.relation.ispartofTurkish Journal of Pediatricsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectatopicen_US
dc.subjectbronchial asthmaen_US
dc.subjectimmunotherapyen_US
dc.subjectautoantibodiesen_US
dc.titleEffect of immunotherapy on autoimmune parameters in children with atopic asthmaen_US
dc.typeArticleen_US

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