Articular cartilage homeostasis after anterior cruciate ligament reconstruction

Basit Öğe Kaydı
dc.contributor.authorTaşkiran E.
dc.contributor.authorTaşkiran D.
dc.contributor.authorDuran T.
dc.contributor.authorLök V.
dc.date.accessioned2019-10-27T00:32:05Z
dc.date.available2019-10-27T00:32:05Z
dc.date.issued1998
dc.departmentEge Üniversitesien_US
dc.description.abstractSeveral factors may be responsible for osteoarthritis after anterior cruciate ligament (ACL) reconstruction. The detrimental effect of the surgical technique may explain part of the progression of the pathologic process. In this study, the effect of ACL reconstruction on articular cartilage was investigated by measuring proteoglycan fragments (PF) in synovial fluid collected from patients who had undergone this operation. Synovial samples were obtained from 44 patients with chronic ACL deficiency aged 26 ± 7 years preoperatively, and from some of them, samples were collected for monitoring at 1 month (n = 22), 3 months (n = 17), 6 months (n = 18) and 12s month (n = 18). Synovial fluid taken from 12 contralateral asymptomatic knees of 12 patients (not necessarily opposite knees of ACL-deficient cases) served as controls. Preoperative values were significantly larger than controls (P < 0.05). PF level reached its maximum value in the 1st month (P < 0.05) and then gradually decreased. It was significantly lower than preoperative values at 6 and 12 months but still greater than controls (P < 0.05). It seems that surgical trauma affects cartilage metabolism for the first 3 months postoperatively. Although reconstruction of the ACL contributes to articular cartilage homeostasis, a complete return to normal values cannot be achieved in 1st postoperative year at least in knees with chronic ACL deficiency. Long-term monitoring is needed to see whether these findings are early signs of osteoarthritis. Further studies may more clearly demonstrate the effect of the surgical procedure on knees with acute and subacute ACL deficiency.en_US
dc.identifier.doi10.1007/s001670050079en_US
dc.identifier.endpage98en_US
dc.identifier.issn0942-2056
dc.identifier.issue2en_US
dc.identifier.pmid9604193en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage93en_US
dc.identifier.urihttps://doi.org/10.1007/s001670050079
dc.identifier.urihttps://hdl.handle.net/11454/23670
dc.identifier.volume6en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer Verlagen_US
dc.relation.ispartofKnee Surgery, Sports Traumatology, Arthroscopyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAnterior cruciate ligamenten_US
dc.subjectArticular cartilage homeostasisen_US
dc.subjectProteoglycan fragmentsen_US
dc.titleArticular cartilage homeostasis after anterior cruciate ligament reconstructionen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

Scopus İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu