Pathogens causing urinary tract infections in infants: a European overview by the ESCAPE study group

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dc.contributor.authorAlberici, Irene
dc.contributor.authorBayazit, Aysun Karabay
dc.contributor.authorDrozdz, Dorota
dc.contributor.authorEmre, Sevinc
dc.contributor.authorFischbach, Michel
dc.contributor.authorHarambat, Jerome
dc.contributor.authorJankauskiene, Augustina
dc.contributor.authorLitwin, Mieczyslaw
dc.contributor.authorMir, Sevgi
dc.contributor.authorMorello, William
dc.contributor.authorPeco-Antic, Amira
dc.contributor.authorSallay, Peter
dc.contributor.authorSever, Lale
dc.contributor.authorSimonetti, Giacomo D.
dc.contributor.authorSzczesniak, Przemyslaw
dc.contributor.authorTeixeira, Ana
dc.contributor.authorVidal, Enrico
dc.contributor.authorWuehl, Elke
dc.contributor.authorMehls, Otto
dc.contributor.authorWeber, Lutz T.
dc.contributor.authorSchaefer, Franz
dc.contributor.authorMontini, Giovanni
dc.date.accessioned2019-10-27T20:24:53Z
dc.date.available2019-10-27T20:24:53Z
dc.date.issued2015
dc.departmentEge Üniversitesien_US
dc.description.abstractKnowledge of the distribution spectrum of causative organisms and their resistance patterns has become a core requirement for the rational and effective management of urinary tract infections. In the context of a prospective trial on the use of antibiotic prophylaxis in infants with underling kidney malformations, we conducted an online survey among paediatric nephrologists on positive urine cultures (July 2010-June 2012) from both hospitalized and non-hospitalized infants under 24 months of age. We collected 4745 urine cultures (UCs) at 18 units in 10 European countries. Escherichia coli was the most frequent bacterium isolated from UCs; however, in 10/16 hospitals and in 6/15 community settings, E. coli was isolated in less than 50 % of the total positive UCs. Other bacterial strains were Klebsiella, Enterococcus, Proteus and Pseudomonas not only from hospital settings. E. coli showed a high resistance to amoxicillin and trimethoprim and variable to cephalosporin. Nitrofurantoin had a good rate of efficacy, with 11/16 hospitals and 11/14 community settings reporting a resistance lower than 5 %. Conclusion: E. coli is the most common organism causing UTIs in infants; however, other bacterial strains are frequently isolated. As a result, antibiotic prophylaxis should be more elastic and adaptable over time in order to guarantee maximum efficacy.en_US
dc.identifier.doi10.1007/s00431-014-2459-3en_US
dc.identifier.endpage790en_US
dc.identifier.issn0340-6199
dc.identifier.issn1432-1076
dc.identifier.issue6en_US
dc.identifier.pmid25428232en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage783en_US
dc.identifier.urihttps://doi.org/10.1007/s00431-014-2459-3
dc.identifier.urihttps://hdl.handle.net/11454/42177
dc.identifier.volume174en_US
dc.identifier.wosWOS:000354904800007en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofEuropean Journal of Pediatricsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectUrinary tract infectionen_US
dc.subjectAntibiotic resistanceen_US
dc.subjectInfantsen_US
dc.subjectEscherichia colien_US
dc.subjectUrine cultureen_US
dc.titlePathogens causing urinary tract infections in infants: a European overview by the ESCAPE study groupen_US
dc.typeArticleen_US

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