Ghrelin ameliorates neuronal damage, oxidative stress, inflammatory parameters, and GFAP expression in traumatic brain injury

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dc.authoridAkyol, Mehmet Edip/0000-0002-5198-0219
dc.authoridAcikgoz, Eda/0000-0002-6772-3081
dc.authoridErgul Erkec, Ozlem/0000-0001-5275-6254
dc.authoridKESKIN, SIDDIK/0000-0001-9355-6558
dc.contributor.authorErkec, Ozlem Ergul
dc.contributor.authorAcikgoz, Eda
dc.contributor.authorHuyut, Zubeyir
dc.contributor.authorAkyol, Mehmet Edip
dc.contributor.authorOzyurt, Enver Onat
dc.contributor.authorKeskin, Siddik
dc.date.accessioned2024-08-31T07:48:27Z
dc.date.available2024-08-31T07:48:27Z
dc.date.issued2024
dc.departmentEge Üniversitesien_US
dc.description.abstractObjectiveThis study investigated the effects of ghrelin on oxidative stress, working memory, inflammatory parameters, and neuron degeneration.MethodsTBI was produced with the weight-drop technique. Rats in the G+TBI and TBI+G groups received ghrelin for 7 days. The control group received saline. On the 8th day of the study, the brain and blood tissue were taken under anesthesia.ResultsA significant increase in brain GSH-PX, MDA, IL-1 beta, TGF-beta 1, and IL-8 levels and a significant decrease in CAT levels were found in the TBI group compared to the control. Serum MDA, GSH, IL-1 beta, and IL-8 levels were increased with TBI. Ghrelin treatment after TBI significantly increased the serum GSH, CAT, GSH-PX, and brain GSH and CAT levels, while it significantly decreased the serum MDA, IL-1 beta, and brain MDA, TGF-beta 1, and IL-8 levels. Histological evaluations revealed that ghrelin treatment led to a reduction in inflammation, while also significantly ameliorating TBI-induced neuron damage and vascular injuries. Immunohistochemistry staining showed that GFAP staining intensity was significantly increased in the cortex and hippocampus in TBI, and GFAP immunoreactivity was decreased with ghrelin treatment.ConclusionThe results from this study suggested that ghrelin may have curative effects on TBI.en_US
dc.description.sponsorshipVan Yuzuncu Yil University Scientific Research Projects Coordination Unit; Van Yuzuncu Yil University Scientific Research Projects Coordination Uniten_US
dc.description.sponsorshipThis work has been supported by Van Yuzuncu Yil University Scientific Research Projects Coordination Unit under [grant number TSA-2021-9340]. The authors want to thank the Van Yuzuncu Yil University Scientific Research Projects Coordination Unit for the financial support.en_US
dc.identifier.doi10.1080/02699052.2024.2324012
dc.identifier.endpage523en_US
dc.identifier.issn0269-9052
dc.identifier.issn1362-301X
dc.identifier.issue7en_US
dc.identifier.pmid38433464en_US
dc.identifier.scopus2-s2.0-85186851228en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage514en_US
dc.identifier.urihttps://doi.org/10.1080/02699052.2024.2324012
dc.identifier.urihttps://hdl.handle.net/11454/104794
dc.identifier.volume38en_US
dc.identifier.wosWOS:001178017000001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofBrain Injuryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240831_Uen_US
dc.subjectGhrelinen_US
dc.subjectTraumatic Brain Injuryen_US
dc.subjectOxidative Stressen_US
dc.subjectInflammationen_US
dc.subjectNeuropeptideen_US
dc.subjectNeurodegenerationen_US
dc.titleGhrelin ameliorates neuronal damage, oxidative stress, inflammatory parameters, and GFAP expression in traumatic brain injuryen_US
dc.typeArticleen_US

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