Global prevalence, treatment, and prevention of hepatitis B virus infection in 2016: a modelling study

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dc.contributor.authorRazavi-Shearer, Devin
dc.contributor.authorGamkrelidze, Ivane
dc.contributor.authorNguyen, Mindie H.
dc.contributor.authorChen, Ding-Shinn
dc.contributor.authorVan Damme, Pierre
dc.contributor.authorAbbas, Zaigham
dc.contributor.authorAbdulla, Maheeba
dc.contributor.authorAbou Rached, Antoine
dc.contributor.authorAdda, Danjuma
dc.contributor.authorAho, Inka
dc.contributor.authorAkarca, Ulus
dc.contributor.authorAl Ali, Fuad Hasan
dc.contributor.authorAl Lawati, Faryal
dc.contributor.authorAl Naamani, Khalid
dc.contributor.authorAlashgar, Hamad Ibrahim
dc.contributor.authorAlavian, Seyed M.
dc.contributor.authorAlawadhi, Sameer
dc.contributor.authorAlbillos, Agustin
dc.contributor.authorAl-Busafi, Said A.
dc.contributor.authorAleman, Soo
dc.contributor.authorAlfaleh, Faleh Z.
dc.contributor.authorAljumah, Abdulrahman A.
dc.contributor.authorAnand, Anil C.
dc.contributor.authorNguyen Thu Anh
dc.contributor.authorArends, Joop E.
dc.contributor.authorArkkila, Perttu
dc.contributor.authorAthanasakis, Kostas
dc.contributor.authorBane, Abate
dc.contributor.authorBen-Ari, Ziv
dc.contributor.authorBerg, Thomas
dc.contributor.authorBizri, Abdul R.
dc.contributor.authorBlach, Sarah
dc.contributor.authorBrandao Mello, Carlos E.
dc.contributor.authorBrandon, Samantha M.
dc.contributor.authorBright, Bisi
dc.contributor.authorBruggmann, Philip
dc.contributor.authorBrunetto, Maurizia
dc.contributor.authorButi, Maria
dc.contributor.authorChan, Henry L. Y.
dc.contributor.authorChaudhry, Asad
dc.contributor.authorChien, Rong-Nan
dc.contributor.authorChoi, Moon S.
dc.contributor.authorChristensen, Peer B.
dc.contributor.authorChuang, Wan-Long
dc.contributor.authorChulanov, Vladimir
dc.contributor.authorClausen, Mette R.
dc.contributor.authorColombo, Massimo
dc.contributor.authorCornberg, Markus
dc.contributor.authorCowie, Benjamin
dc.contributor.authorCraxi, Antonio
dc.contributor.authorCroes, Esther A.
dc.contributor.authorAlberto Cuellar, Diego
dc.contributor.authorCunningham, Chris
dc.contributor.authorDesalegn, Hailemichael
dc.contributor.authorDrazilova, Sylvia
dc.contributor.authorDuberg, Ann-Sofi
dc.contributor.authorEgeonu, Steve S.
dc.contributor.authorEl-Sayed, Manal H.
dc.contributor.authorEstes, Chris
dc.contributor.authorFalconer, Karolin
dc.contributor.authorFerraz, Maria L. G.
dc.contributor.authorFerreira, Paulo R.
dc.contributor.authorFlisiak, Robert
dc.contributor.authorFrankova, Sona
dc.contributor.authorGaeta, Giovanni B.
dc.contributor.authorGarcia-Samaniego, Javier
dc.contributor.authorGenov, Jordan
dc.contributor.authorGerstoft, Jan
dc.contributor.authorGoldis, Adrian
dc.contributor.authorGountas, Ilias
dc.contributor.authorGray, Richard
dc.contributor.authorPessoa, Mario Guimaraes
dc.contributor.authorHajarizadeh, Behzad
dc.contributor.authorHatzakis, Angelos
dc.contributor.authorHezode, Christophe
dc.contributor.authorHimatt, Sayed M.
dc.contributor.authorHoepelman, Andy
dc.contributor.authorHrstic, Irena
dc.contributor.authorHui, Yee-Tak T.
dc.contributor.authorHusa, Petr
dc.contributor.authorJahis, Rohani
dc.contributor.authorJanjua, Naveed Z.
dc.contributor.authorJarcuska, Peter
dc.contributor.authorJaroszewicz, Jerzy
dc.contributor.authorKaymakoglu, Sabahattin
dc.contributor.authorKershenobich, David
dc.contributor.authorKondili, Loreta A.
dc.contributor.authorKonysbekova, Aliya
dc.contributor.authorKrajden, Mel
dc.contributor.authorKristian, Pavol
dc.contributor.authorLaleman, Wim
dc.contributor.authorLao, Wai-cheung C.
dc.contributor.authorLayden, Jen
dc.contributor.authorLazarus, Jeffrey V.
dc.contributor.authorLee, Mei-Hsuan
dc.contributor.authorLiakina, Valentina
dc.contributor.authorLim, Young-Suk S.
dc.contributor.authorLoo, Ching-kong K.
dc.contributor.authorLuksic, Boris
dc.contributor.authorMalekzadeh, Reza
dc.contributor.authorMalu, Abraham O.
dc.contributor.authorMamatkulov, Adkhamjon
dc.contributor.authorManns, Michael
dc.contributor.authorMarinho, Rui T.
dc.contributor.authorMaticic, Mojca
dc.contributor.authorMauss, Stefan
dc.contributor.authorMemon, Muhammad S.
dc.contributor.authorMendes Correa, Maria C.
dc.contributor.authorMendez-Sanchez, Nahum
dc.contributor.authorMerat, Shahin
dc.contributor.authorMetwally, Ammal M.
dc.contributor.authorMohamed, Rosmawati
dc.contributor.authorMokhbat, Jacques E.
dc.contributor.authorMoreno, Christophe
dc.contributor.authorMossong, Joel
dc.contributor.authorMourad, Fadi H.
dc.contributor.authorMullhaupt, Beat
dc.contributor.authorMurphy, Kimberly
dc.contributor.authorMusabaev, Erkin
dc.contributor.authorNawaz, Arif
dc.contributor.authorNde, Helen M.
dc.contributor.authorNegro, Francesco
dc.contributor.authorNersesov, Alexander
dc.contributor.authorVan Thi Thuy Nguyen
dc.contributor.authorNjouom, Richard
dc.contributor.authorNtagirabiri, Renovat
dc.contributor.authorNurmatov, Zuridin
dc.contributor.authorObekpa, Solomon
dc.contributor.authorOcama, Ponsiano
dc.contributor.authorOguche, Stephen
dc.contributor.authorOmede, Ogu
dc.contributor.authorOmuemu, Casimir
dc.contributor.authorOpare-Sem, Ohene
dc.contributor.authorOpio, Christopher K.
dc.contributor.authorOrmeci, Necati
dc.contributor.authorPapatheodoridis, George
dc.contributor.authorPasini, Ken
dc.contributor.authorPimenov, Nikolay
dc.contributor.authorPoustchi, Hossein
dc.contributor.authorQuang, Tran D.
dc.contributor.authorQureshi, Huma
dc.contributor.authorRamji, Alnoor
dc.contributor.authorRazavi-Shearer, Kathryn
dc.contributor.authorRedae, Berhane
dc.contributor.authorReesink, Henk W.
dc.contributor.authorYaneth Rios, Cielo
dc.contributor.authorRjaskova, Gabriela
dc.contributor.authorRobbins, Sarah
dc.contributor.authorRoberts, Lewis R.
dc.contributor.authorRoberts, Stuart K.
dc.contributor.authorRyder, Stephen D.
dc.contributor.authorSafadi, Rifaat
dc.contributor.authorSagalova, Olga
dc.contributor.authorSalupere, Riina
dc.contributor.authorSanai, Faisal M.
dc.contributor.authorSanchez-Avila, Juan F.
dc.contributor.authorSaraswat, Vivek
dc.contributor.authorSarrazin, Christoph
dc.contributor.authorSchmelzer, Jonathan D.
dc.contributor.authorSchreter, Ivan
dc.contributor.authorScott, Julia
dc.contributor.authorSeguin-Devaux, Carole
dc.contributor.authorShah, Samir R.
dc.contributor.authorSharara, Ala I.
dc.contributor.authorSharma, Manik
dc.contributor.authorShiha, Gamal E.
dc.contributor.authorShin, Tesia
dc.contributor.authorSievert, William
dc.contributor.authorSperl, Jan
dc.contributor.authorStarkel, Peter
dc.contributor.authorStedman, Catherine
dc.contributor.authorSypsa, Vana
dc.contributor.authorTacke, Frank
dc.contributor.authorTan, Soek S.
dc.contributor.authorTanaka, Junko
dc.contributor.authorTomasiewicz, Krzysztof
dc.contributor.authorUrbanek, Petr
dc.contributor.authorvan der Meer, Adriaan J.
dc.contributor.authorVan Vlierberghe, Hans
dc.contributor.authorVella, Stefano
dc.contributor.authorVince, Adriana
dc.contributor.authorWaheed, Yasir
dc.contributor.authorWaked, Imam
dc.contributor.authorWalsh, Nicholas
dc.contributor.authorWeis, Nina
dc.contributor.authorWong, Vincent W.
dc.contributor.authorWoodring, Joseph
dc.contributor.authorYaghi, Cesar
dc.contributor.authorYang, Hwai-, I
dc.contributor.authorYang, Chung-Lin
dc.contributor.authorYesmembetov, Kakharman
dc.contributor.authorYosry, Ayman
dc.contributor.authorYuen, Man-Fung
dc.contributor.authorYusuf, Muhammed Aasim M.
dc.contributor.authorZeuzem, Stefan
dc.contributor.authorRazavi, Homie
dc.date.accessioned2019-10-27T10:05:02Z
dc.date.available2019-10-27T10:05:02Z
dc.date.issued2018
dc.departmentEge Üniversitesien_US
dc.description.abstractBackground The 69th World Health Assembly approved the Global Health Sector Strategy to eliminate viral hepatitis by 2030. Although no virological cure exists for hepatitis B virus (HBV) infection, existing therapies to control viral replication and prophylaxis to minimise mother-to-child transmission make elimination of HBV feasible. We aimed to estimate the national, regional, and global prevalence of HBsAg in the general population and in the population aged 5 years in 2016, as well as coverage of prophylaxis, diagnosis, and treatment. Methods In this modelling study, we used a Delphi process that included a literature review in PubMed and Embase, followed by interviews with experts, to quantify the historical epidemiology of HBV infection. We then used a dynamic HBV transmission and progression model to estimate the country-level and regional-level prevalence of HBsAg in 2016 and the effect of prophylaxis and treatment on disease burden. Findings We developed models for 120 countries, 78 of which were populated with data approved by experts. Using these models, we estimated that the global prevalence of HBsAg in 2016 was 3.9% (95% uncertainty interval [UI] 3.4-4.6), corresponding to 291 992 000 (251 513 000-341 114 000) infections. Of these infections, around 29 million (10%) were diagnosed, and only 4.8 million (5%) of 94 million individuals eligible for treatment actually received antiviral therapy. Around 1.8 (1.6-2.2) million infections were in children aged 5 years, with a prevalence of 1.4% (1.2-1.6). We estimated that 87% of infants had received the three-dose HBV vaccination in the first year of life, 46% had received timely birth-dose vaccination, and 13% had received hepatitis B immunoglobulin along with the full vaccination regimen. Less than 1% of mothers with a high viral load had received antiviral therapy to reduce mother-to-child transmission. Interpretation Our estimate of HBV prevalence in 2016 differs from previous studies, potentially because we took into account the effect of infant prophylaxis and early childhood vaccination, as well as changing prevalence over time. Although some regions are well on their way to meeting prophylaxis and prevalence targets, all regions must substantially scale-up access to diagnosis and treatment to meet the global targets. Funding John C Martin Foundation. Copyright (c) 2018 Elsevier Ltd. All rights reserved.en_US
dc.description.sponsorshipJohn C Martin Foundationen_US
dc.description.sponsorshipJohn C Martin Foundation.en_US
dc.identifier.doi10.1016/S2468-1253(18)30056-6en_US
dc.identifier.endpage403en_US
dc.identifier.issn2468-1253
dc.identifier.issue6en_US
dc.identifier.pmid29599078en_US
dc.identifier.startpage383en_US
dc.identifier.urihttps://doi.org/10.1016/S2468-1253(18)30056-6
dc.identifier.urihttps://hdl.handle.net/11454/30309
dc.identifier.volume3en_US
dc.identifier.wosWOS:000436553600019en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Incen_US
dc.relation.ispartofLancet Gastroenterology & Hepatologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleGlobal prevalence, treatment, and prevention of hepatitis B virus infection in 2016: a modelling studyen_US
dc.typeArticleen_US

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