May ganglion cell complex analysis be a marker for glaucoma susceptibility in unilateral Fuchs' uveitis syndrome?

Basit Öğe Kaydı
dc.authoridsaritepe imre, seher/0000-0002-1063-4299
dc.authoridBalikoglu-Yilmaz, Melike/0000-0002-3823-211X
dc.authoridDoganay Kumcu, Nur/0000-0003-3894-3883
dc.authoridozgul, semiha/0000-0002-0220-1207
dc.authoridAydin, Erdinc/0000-0002-0843-3201
dc.authorscopusid36553797600
dc.authorscopusid57218937126
dc.authorscopusid54884242300
dc.authorscopusid57209240154
dc.authorscopusid57191538041
dc.authorscopusid57212220169
dc.authorscopusid6701658370
dc.authorwosidKOSE, Timur/ABH-3197-2021
dc.contributor.authorYilmaz, Melike Balikoglu
dc.contributor.authorKumcu, Nur Doganay
dc.contributor.authorDaldal, Hatice
dc.contributor.authorImre, Seher Saritepe
dc.contributor.authorAydin, Erdinc
dc.contributor.authorOzgul, Semiha
dc.contributor.authorKose, Timur
dc.date.accessioned2023-01-12T19:50:11Z
dc.date.available2023-01-12T19:50:11Z
dc.date.issued2021
dc.departmentN/A/Departmenten_US
dc.description.abstractPurpose To compare retinal nerve fiber layer (RNFL) thickness and ganglion cell-inner plexiform layer thickness (GCIPLT) in the affected eyes to fellow unaffected eyes of patients with unilateral Fuchs' uveitis syndrome (FUS) and analyze their change over time. Methods Twenty seven unilateral FUS patients who did not have concomitant systemic or ocular disease were retrospectively enrolled. Central macular thickness (CMT), RNFL thickness, and GCIPLT measurements were evaluated. Data was analyzed using the non-parametric Brunner-Langer model (LD-F2 design) and Wilcoxon signed-rank test. Results The mean age of the patients was 40.2 +/- 10.2 years. The median disease duration was 11 (2-62) months. The median best-corrected visual acuity (BCVA) of the affected eyes and the fellow eyes was 0.22 (0.00-2.50) vs. 0.00 (0.0-0.10) logMAR at the initial visit and 0.05 (0.00-2.50) vs. 0.00 (0.0-0.30) logMAR at the final visit. The change in BCVA was found significant in the affected eyes, but not in the fellow eyes (p < 0.001 and p = 0.287, respectively). The median CMT in the affected eyes at the final visit was not statistically different from the value at the initial visit (255 (157-306) vs. 245 (140-310) mu m, p = 0.256). The change in RNFL thickness over time in the affected eyes was similar to the fellow unaffected eyes of the patients with unilateral FUS at all quadrants, with non-significant time and group effects (p > 0.05). However, median GCIPLT in all quadrants (except superonasal) in the affected eyes was statistically lower than the fellow eyes at the initial and final visits (p < 0.05). The most affected quadrant of the ganglion cell complex was inferonasal in the involved eyes (79 (42-97) vs. 75 (43-87) mu m) at initial and final visits (p = 0.033 for time effect and p < 0.001 for group effect, respectively). Conclusion Median CMT and RNFL thickness did not change during follow-up in the affected eyes of patients with unilateral FUS. Median GCIPLT in the affected eyes declined over time in all quadrants. Ganglion cell loss was also most prominent in the inferonasal quadrant in the affected eyes. FUS patients should be followed up long-term in terms of ganglion cell loss, especially in the inferonasal quadrant.en_US
dc.identifier.doi10.1007/s00417-021-05182-4
dc.identifier.endpage1983en_US
dc.identifier.issn0721-832X
dc.identifier.issn1435-702X
dc.identifier.issue7en_US
dc.identifier.pmid33929589en_US
dc.identifier.scopus2-s2.0-85105418114en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1975en_US
dc.identifier.urihttps://doi.org/10.1007/s00417-021-05182-4
dc.identifier.urihttps://hdl.handle.net/11454/76042
dc.identifier.volume259en_US
dc.identifier.wosWOS:000645886900001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofGraefes Archive For Clinical and Experimental Ophthalmologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectFuchs' uveitis syndromeen_US
dc.subjectCentral macular thicknessen_US
dc.subjectGanglion cell-inner plexiform layer thicknessen_US
dc.subjectRetinal nerve fiber layer thicknessen_US
dc.subjectOptical Coherence Tomographyen_US
dc.subjectNerve-Fiber Layeren_US
dc.subjectChoroidal Thicknessen_US
dc.subjectHeterochromic Iridocyclitisen_US
dc.subjectClinical-Featuresen_US
dc.subjectAssociationen_US
dc.subjectEyesen_US
dc.titleMay ganglion cell complex analysis be a marker for glaucoma susceptibility in unilateral Fuchs' uveitis syndrome?en_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu