Effects of ovariectomy and tamoxifen on rat bone tissue - Histomorphometric and histopathologic study

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dc.contributor.authorAktug, Huseyin
dc.contributor.authorUslu, Serap
dc.contributor.authorTerek, Mustafa Cosan
dc.contributor.authorTerzi, Hasan
dc.contributor.authorTurgut, Mehmet
dc.contributor.authorOzsener, Serdar
dc.contributor.authorBilgin, Onur
dc.date.accessioned2019-10-27T19:17:35Z
dc.date.available2019-10-27T19:17:35Z
dc.date.issued2006
dc.departmentEge Üniversitesien_US
dc.description.abstractOBJECTIVE: To investigate possible detrimental effects on bone tissue induced by ovariectomy and tamoxifen (TMX) using bone densitometry and histomorphologic analysis. STUDY DESIGN. Twenty-four rats were allocated into 4 groups: group 1, intact normal rats (n = 6); group 2, ovariectomized rats (n = 6); group 3, normal female rats that received 1 mg/kg/day TMX dissolved in dimethyl sulfoxide (DMSO)for 2 months (n = 6); group 4, normal female rats that received DMSO for the same duration and with a volume equal to that of TMX (n = 6). Results of histomorphometric analysis for trabecular thickness, number of osteoblasts and osteoclasts, trabecular number, and area and cortical thickness were compared. RESULTS: No significant effects of ovariectomy on femoral or lumbar bone mineral density (BMD) were found. In the TMX group, the value of femoral BMD increased significantly compared to control group cellular and pathologic changes. TMX caused significant decrease in osteoblasts compared to the control group. CONCLUSION: TMX has a positive effect on inorganic bone tissue, but a negative effect on number of osteoblasts and osteoclasts. Future studies investigating estrogenic and antiestrogenic effects of TMX should include cellular parameters related to proliferation using histopathologic and histomorphometric analyses.en_US
dc.identifier.endpage212en_US
dc.identifier.issn0884-6812
dc.identifier.issue4en_US
dc.identifier.pmid16927640en_US
dc.identifier.startpage207en_US
dc.identifier.urihttps://hdl.handle.net/11454/38422
dc.identifier.volume28en_US
dc.identifier.wosWOS:000239524400004en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSci Printers & Publ Incen_US
dc.relation.ispartofAnalytical and Quantitative Cytology and Histologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectboneen_US
dc.subjecthistologyen_US
dc.subjecthistomorphologyen_US
dc.subjectovariectomyen_US
dc.subjecttamoxifenen_US
dc.titleEffects of ovariectomy and tamoxifen on rat bone tissue - Histomorphometric and histopathologic studyen_US
dc.typeArticleen_US

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