Evaluation of the effect of intensity-modulated radiotherapy (IMRT) and volumetric-modulated arc radiotherapy (VMAT) techniques on survival response in cell lines with a new radiobiological modeling

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dc.authoridTavlayan, Emin/0000-0003-0177-1571
dc.authorscopusid6508205483
dc.authorscopusid54889084200
dc.authorscopusid57200561400
dc.authorscopusid56497855800
dc.authorscopusid57191416192
dc.authorscopusid55608300300
dc.authorscopusid47562303600
dc.contributor.authorKamer, Serra
dc.contributor.authorYılmaz Süslüer, Sunde
dc.contributor.authorBalcı Okcanoğlu, Tuğce
dc.contributor.authorKayabasi, Çağla
dc.contributor.authorÖzmen Yelken, Besra
dc.contributor.authorHoca, Sinan
dc.contributor.authorTavlayan, Emin
dc.date.accessioned2024-08-25T18:48:11Z
dc.date.available2024-08-25T18:48:11Z
dc.date.issued2023
dc.departmentEge Üniversitesien_US
dc.description.abstractBackground: The optimal radiobiological model, which assesses the biological effects of novel radiotherapy techniques that concurrently modify multiple physical factors, has not yet been defined. This study aimed to investigate the impact of intensity-modulated radiotherapy (IMRT) and volumetric-modulated arc therapy (VMAT) on cellular response in head and neck cancer and melanoma models.Methods: Clonogenic analysis, DNA double-strand break analysis, apoptosis, and cell cycle analysis were performed on cancer stem cell models, cancer models, and normal tissue cell models to assess radiation sensitivity.Results: The segmented radiation approach used in IMRT applications enhanced radiosensitivity and cytotoxicity in the cancer models, while changes in dose rate had varying effects on cytotoxicity depending on the tumor cell type. VMAT increased cellular resistance, favoring treatment outcomes.Conclusions: The biological processes were influenced differently by dose rate, IMRT, and VMAT depending on the tumor cell type. The selection of the most appropriate technique is crucial in representing new radiotherapy approaches. The obtained data can serve as a model to address clinical questions in daily practice. The integration of non-standard outcomes with standard applications should be considered in clinical settings.en_US
dc.description.sponsorshipTurkiye Bilimsel ve Teknolojik Arastirma Kurumu [113S367]; Turkiye Bilimsel ve Teknolojik Arastirma Kurumu [113S367]en_US
dc.description.sponsorshipTurkiye Bilimsel ve Teknolojik Arastirma Kurumu, Grant/Award Number: 113S367en_US
dc.identifier.doi10.1002/cam4.6593
dc.identifier.issn2045-7634
dc.identifier.pmid37754559en_US
dc.identifier.scopus2-s2.0-85172781968en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1002/cam4.6593
dc.identifier.urihttps://hdl.handle.net/11454/102183
dc.identifier.wosWOS:001074951400001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofCancer Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz20240825_Gen_US
dc.subjectcell survivalen_US
dc.subjectIMRTen_US
dc.subjectradiotherapy techniquesen_US
dc.subjectVMATen_US
dc.subjectCancer Stem-Cellsen_US
dc.subjectRadiationen_US
dc.subjectTherapyen_US
dc.subjectFutureen_US
dc.titleEvaluation of the effect of intensity-modulated radiotherapy (IMRT) and volumetric-modulated arc radiotherapy (VMAT) techniques on survival response in cell lines with a new radiobiological modelingen_US
dc.typeArticleen_US

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