Synthesis and investigation of anticancer potential of radiolabeled naphthalene monoimide bearing imidazolium salt

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dc.contributor.authorLambrecht, Fatma Yurt
dc.contributor.authorOcakoglu, Kasim
dc.contributor.authorColak, Suleyman Gokhan
dc.contributor.authorErsoz, Onur Alp
dc.contributor.authorEr, Ozge
dc.date.accessioned2019-10-27T11:07:04Z
dc.date.available2019-10-27T11:07:04Z
dc.date.issued2017
dc.departmentEge Üniversitesien_US
dc.description.abstractImidazolium salts and derivatives have antitumor efficacy and toxic effects in different micro-organisms. In this study, an imidazolium bromide salt (NMI) was synthesized, and its antitumor potential was investigated by in vitro studies. Radiolabeling of synthesized NMI was carried out by iodogen method using I-131 radionuclide. The yield of radiolabeling was determined as 98.5 +/- 0.1%. After that, cytotoxicity and intracellular uptake studies were evaluated in various cell lines. The cytotoxicity of NMI was determined as 35, 20, 10, and 1 mu m for HEK-293, PC-3, CaCo-2, and MCF-7 cells, respectively. In addition, the intracellular uptake of I-131-NMI was investigated in the cell lines, and the uptake was significantly found as 4 hr for MCF-7 and 6 hr for PC-3. In future studies, antitumor efficacy of I-131-NMI on tumor-bearing animal model might be studied in light of these results.en_US
dc.description.sponsorshipDepartment of Scientific Projects at Ege University, Izmir, TurkeyEge University [BAP 14 NBE007]en_US
dc.description.sponsorshipDepartment of Scientific Projects at Ege University, Izmir, Turkey, Grant/Award Number: (BAP 14 NBE007).en_US
dc.identifier.doi10.1111/cbdd.12935en_US
dc.identifier.endpage146en_US
dc.identifier.issn1747-0277
dc.identifier.issn1747-0285
dc.identifier.issue1en_US
dc.identifier.pmid28067001en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage141en_US
dc.identifier.urihttps://doi.org/10.1111/cbdd.12935
dc.identifier.urihttps://hdl.handle.net/11454/31971
dc.identifier.volume90en_US
dc.identifier.wosWOS:000405102600012en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofChemical Biology & Drug Designen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectI-131en_US
dc.subjectanticancer potentialen_US
dc.subjectimidazolium saltsen_US
dc.subjectnuclear medicineen_US
dc.subjectRadiolabelingen_US
dc.titleSynthesis and investigation of anticancer potential of radiolabeled naphthalene monoimide bearing imidazolium salten_US
dc.typeArticleen_US

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