Plaque Accumulation and Inflammation Adjacent to Restorations of Amorphous Calcium Phosphate-containin Composite in Early Childhood Caries

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dc.contributor.authorGurlek, Ceren
dc.contributor.authorErtugrul, Fahinur
dc.contributor.authorNile, Christopher
dc.contributor.authorLappin, David F.
dc.contributor.authorBuduneli, Nurcan
dc.date.accessioned2019-10-27T10:02:30Z
dc.date.available2019-10-27T10:02:30Z
dc.date.issued2018
dc.departmentEge Üniversitesien_US
dc.description.abstractPurpose: To evaluate the clinical, biochemical, and microbiological reactions to nanocomposite containing amorphous calcium phosphate (ACP) in comparison to a traditional composite restorative material in early childhood caries. Materials and Methods: Eighteen teeth were restored with the test material (ACP-containing resin) and 18 teeth were restored with the control material (traditional composite, TC) in fourteen paediatric patients using a splitmouth design. One caries- and restoration-free intact tooth in each patient was selected as the healthy control. Gingival crevicular fluid (GCF) and supragingival plaque samples were collected at baseline before the treatment and also on days 1, 7, 14 and 30 after treatment. Unstimulated whole saliva samples were obtained from each patient at baseline, and 1 and 6 months after restoration. GCF and saliva samples were assayed for IL-17A, IL-17F IL-17A/F, IL-17E, OPG and RANKL levels by ELISA, and plaque composition was assessed using RT-PCR. Results: Clinical evaluation indicated no statistically significant differences between the two restorative materials according to the FDI criteria surface lustre, material retention and marginal adaptation properties. Pro-inflammatory IL-17 levels decreased statistically significantly at 6 months compared to baseline and 1-month values (p < 0.05). The baseline pro-inflammatory IL-17 cytokine levels in GCF samples around the carious teeth were higher than those obtained around the healthy teeth (p < 0.05), but similar in GCF from the ACP-test and TC teeth. Microbiological findings were similar in the ACP and T groups. Conclusion: It may be suggested that both ACP-containing and traditional resin composites show similar antimicrobial and biochemical effects in early childhood caries.en_US
dc.description.sponsorshipEge University Research FoundationEge University [2013 DIS 033]; University of Glasgow [SC004401]en_US
dc.description.sponsorshipThis study was funded by a grant from the Ege University Research Foundation (Project No: 2013 DIS 033) and by funding from The University of Glasgow (Registered charity number SC004401).en_US
dc.identifier.doi10.3290/j.ohpd.a41361en_US
dc.identifier.endpage465en_US
dc.identifier.issn1602-1622
dc.identifier.issn1757-9996
dc.identifier.issue5en_US
dc.identifier.pmid30460359en_US
dc.identifier.startpage457en_US
dc.identifier.urihttps://doi.org/10.3290/j.ohpd.a41361
dc.identifier.urihttps://hdl.handle.net/11454/29996
dc.identifier.volume16en_US
dc.identifier.wosWOS:000453409100010en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherQuintessence Publishing Co Incen_US
dc.relation.ispartofOral Health & Preventive Dentistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectamorphous calcium phosphateen_US
dc.subjectcytokinesen_US
dc.subjectearly childhood cariesen_US
dc.subjectGCFen_US
dc.subjectplaqueen_US
dc.subjectsalivaen_US
dc.titlePlaque Accumulation and Inflammation Adjacent to Restorations of Amorphous Calcium Phosphate-containin Composite in Early Childhood Cariesen_US
dc.typeArticleen_US

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