Effects of Hormone Replacement Therapy on Insulin Resistance and Platelet Function Tests

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dc.contributor.authorSarac, Fulden
dc.contributor.authorSaydam, Güray
dc.contributor.authorSahin, Fahri
dc.contributor.authorOztekin, Kemal
dc.contributor.authorSaygili, Fusun
dc.contributor.authorTuzun, Mehmet
dc.contributor.authorYilmaz, Candeger
dc.date.accessioned2019-10-27T20:21:23Z
dc.date.available2019-10-27T20:21:23Z
dc.date.issued2009
dc.departmentEge Üniversitesien_US
dc.description.abstractObjectives: The aim of this study was to evaluate measures of insulin resistance and platelet function in postmenopausal women with oral or transdermal hormone replacement therapy (HRT). Subjects and Methods: Eighty women divided into four groups of 20 each were enrolled in the study. Group 1: postmenopausal hysterectomized women who received only transdermal estradiol (13.9 mg/12.5 cm(2)); group 2: women with intact uterus who were treated with estrogen-progestin combination ( HRT); group 3: postmenopausal women who were treated with the selective estrogen receptor modulator tibolone, and group 4: women who were not taking any drugs for HRT were chosen as a control group ( group 4). Results: In group 2, homeostasis model assessment of insulin resistance and fasting insulin levels were 2.90 +/- 0.37 and 9.3 +/- 3.0 mu U/ml, respectively, prior to administration of HRT. These levels were reduced to 1.91 +/- 0.41 (p = 0.001) and 7.1 +/- 2.7 mu U/ml (p = 0.002), respectively, after drug therapy. Mean levels of high-sensitivity C-reactive protein (hsCRP) were decreased with HRT only in group 2 (p = 0.002). No changes for biochemical and hematological parameters were observed in the other groups. Platelet function tests showed no differences after HRT in any group. Conclusions: Estrogen-progestin combination HRT decreased measures of insulin resistance and hsCRP levels, but had no effect on platelet function tests in postmenopausal women. Copyright (C) 2008 S. Karger AG, Baselen_US
dc.identifier.doi10.1159/000163045en_US
dc.identifier.endpage47en_US
dc.identifier.issn1011-7571
dc.identifier.issue1en_US
dc.identifier.pmid19060490en_US
dc.identifier.startpage43en_US
dc.identifier.urihttps://doi.org/10.1159/000163045
dc.identifier.urihttps://hdl.handle.net/11454/41754
dc.identifier.volume18en_US
dc.identifier.wosWOS:000261385800008en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherKargeren_US
dc.relation.ispartofMedical Principles and Practiceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectInsulin resistanceen_US
dc.subjectPlatelet functionen_US
dc.subjectHormone replacementen_US
dc.subjectPostmenopausal womenen_US
dc.titleEffects of Hormone Replacement Therapy on Insulin Resistance and Platelet Function Testsen_US
dc.typeArticleen_US

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