Effect of celecoxib on intra-abdominal sepsis-induced lung injury in rats

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dc.contributor.authorDıbekoglu, Cengiz
dc.contributor.authorBora, Ejder Saylav
dc.contributor.authorEroğlu, Ebru
dc.contributor.authorYurtsever, Güner
dc.contributor.authorUyanıkgil, Yiğit
dc.contributor.authorErbaş, Oytun
dc.date.accessioned2024-08-25T18:52:10Z
dc.date.available2024-08-25T18:52:10Z
dc.date.issued2023
dc.departmentEge Üniversitesien_US
dc.description.abstractObjectives: This experimental study investigated the preventive effects of Celecoxib, a selective COX-2 inhibitor, on lung injury induced by intra-abdominal sepsis in rats. The study assessed Celecoxib's potential to mitigate the harmful impacts of sepsis on lung tissue. Methods: Thirty male Wistar albino rats, divided into three groups: a normal control group, a sepsis-induced group treated with saline, and a sepsis-induced group treated with Celecoxib. Sepsis was induced using fecal intraperitoneal injection (FIP), followed by a one-hour administration of Celecoxib at 50 mg/kg/day to the treatment group. Biochemical analysis of lung tissue measured oxidative stress markers (malondialdehyde [MDA]) and pro-inflammatory cytokines (Tumor Necrosis Faftor-? [TNF-?]). Histopathological examination evaluated lung tissue damage, encompassing alveolar congestion, hemorrhage, inflammatory cell aggregation, and edema. Arterial blood gas analysis quantified partial oxygen (PaO2) and carbon dioxide (PaCO2) pressures. Results: Celecoxib-treated rats exhibited reduced oxidative stress markers with lower MDA levels, indicating decreased oxidative damage in lung tissue. Moreover, TNF-? and other pro-inflammatory cytokines were significantly reduced in lung tissues of Celecoxib-treated rats, indicating its anti-inflammatory effects. Histopathological examination revealed reduced lung tissue damage in Celecoxib-treated rats, including alveolar congestion, hemorrhage, and inflammatory cell aggregation. Arterial blood gas analysis showed improved oxygenation (PaO2) in the Celecoxib-treated group compared to untreated sepsis rats. Conclusions: Celecoxib demonstrated preventive effects against sepsis-induced lung injury in rats by mitigating oxidative stress and inflammation, thereby preserving lung tissue integrity—further research, including clinical trials, to validate its effectiveness and safety in human sepsis management.en_US
dc.identifier.doi10.18621/eurj.1333071
dc.identifier.endpage1156en_US
dc.identifier.issn2149-3189
dc.identifier.issue5en_US
dc.identifier.startpage1149en_US
dc.identifier.trdizinid1194890en_US
dc.identifier.urihttps://doi.org/10.18621/eurj.1333071
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1194890
dc.identifier.urihttps://hdl.handle.net/11454/102870
dc.identifier.volume9en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofThe European Research Journalen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz20240825_Gen_US
dc.titleEffect of celecoxib on intra-abdominal sepsis-induced lung injury in ratsen_US
dc.typeArticleen_US

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