Successful application of chemosaturation with percutaneous hepatic perfusion in metastatic uveal melanoma patient progressing after systemic treatment options: a case report

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dc.authoridgünenç, damla/0000-0002-7592-2021
dc.contributor.authorGunenc, Damla
dc.contributor.authorOzluk, Ahmet Anil
dc.contributor.authorYildirim, Utku Mahir
dc.contributor.authorAscierto, Paolo A.
dc.contributor.authorKaraca, Burcak
dc.date.accessioned2024-08-31T07:50:37Z
dc.date.available2024-08-31T07:50:37Z
dc.date.issued2024
dc.departmentEge Üniversitesien_US
dc.description.abstractUveal melanoma (UM) is a rare subtype of melanoma, accounting for less than 5% of all melanoma cases. Metastatic UM differs notably from cutaneous melanoma, exhibiting variations in etiology, prognosis, driver mutations, metastatic patterns, and poor responses to immune checkpoint inhibitors (ICI). Beyond local treatment options, such as resection, radiation therapy, and enucleation, and systemic treatments, such as ICIs, the approval of tebentafusp, a bispecific gp100 peptide-HLA-directed CD3 T-cell engager, marks a breakthrough in treating HLA-A*02:01 metastatic UM. Despite the advancements in treatment options, the long-term survival rates remain inadequate. We report a patient with metastatic UM who previously received ICI and progressed on tebentafusp treatment but subsequently exhibited a remarkable response to local treatment targeting liver metastasis. Such observations highlight the significance of exploring sequential therapeutic strategies for advanced UM, offering potential avenues to enhance treatment efficacy and patient prognosis.en_US
dc.identifier.doi10.3389/fonc.2024.1355971
dc.identifier.issn2234-943X
dc.identifier.pmid38660135en_US
dc.identifier.scopus2-s2.0-85191045773en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.3389/fonc.2024.1355971
dc.identifier.urihttps://hdl.handle.net/11454/105304
dc.identifier.volume14en_US
dc.identifier.wosWOS:001207274800001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherFrontiers Media Saen_US
dc.relation.ispartofFrontiers In Oncologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz20240831_Uen_US
dc.subjectUveal Melanomaen_US
dc.subjectChemosaturationen_US
dc.subjectImmune Checkpoint Inhibitorsen_US
dc.subjectTebentafuspen_US
dc.subjectLiveren_US
dc.subjectPercutaneous Hepatic Perfusionen_US
dc.titleSuccessful application of chemosaturation with percutaneous hepatic perfusion in metastatic uveal melanoma patient progressing after systemic treatment options: a case reporten_US
dc.typeArticleen_US

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