Role of a second transplantation for children with acute leukemia following posttransplantation relapse: a study by the Turkish Bone Marrow Transplantation Study Group

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dc.contributor.authorHazar, Volkan
dc.contributor.authorKarasu, Gulsun Tezcan
dc.contributor.authorUygun, Vedat
dc.contributor.authorOzbek, Namik
dc.contributor.authorKarakukcu, Musa
dc.contributor.authorOzturk, Gulyuz
dc.contributor.authorOk Bozkaya, Ikbal
dc.date.accessioned2020-12-01T12:02:35Z
dc.date.available2020-12-01T12:02:35Z
dc.date.issued2020
dc.departmentEge Üniversitesien_US
dc.description.abstractWe examined outcomes of 51 pediatric patients with relapsed acute leukemia (AL) who underwent a second allogeneic hematopoietic stem cell transplantation (alloHSCT). After a median follow-up of 941 days (range, 69-2842 days), leukemia-free survival (LFS) and overall survival (OS) at 3 years were 26.6% and 25.6%, respectively. the nonrelapse mortality rate (NMR) and cumulative incidence of relapse (CIR) were 36.4% and 42.4%, respectively. the Cox regression analysis demonstrated that the risk factors at second transplantation for predicting limited LFS were active disease (hazard ratio (HR) = 5.1), reduced intensity conditioning (RIC) (HR = 5.0), matched unrelated donor (MUD) (HR = 3.4) and performance score <80 (HR = 3.2). Pediatric patients with AL who relapsed after their first alloHSCT may survive with a second alloHSCT. Disease status, conditioning intensity, donor type, and performance score at the second transplantation are the relevant risk factors. A score based on these factors may predict the results of the second transplantation.en_US
dc.identifier.doi10.1080/10428194.2020.1716220en_US
dc.identifier.endpage1474en_US
dc.identifier.issn1042-8194
dc.identifier.issn1029-2403
dc.identifier.issue6en_US
dc.identifier.pmid32037917en_US
dc.identifier.scopus2-s2.0-85079443526en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1465en_US
dc.identifier.urihttps://doi.org/10.1080/10428194.2020.1716220
dc.identifier.urihttps://hdl.handle.net/11454/62709
dc.identifier.volume61en_US
dc.identifier.wosWOS:000513301500001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofLeukemia & Lymphomaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPosttransplantation relapseen_US
dc.subjectsecond transplantationen_US
dc.subjectacute leukemiaen_US
dc.subjectchildrenen_US
dc.titleRole of a second transplantation for children with acute leukemia following posttransplantation relapse: a study by the Turkish Bone Marrow Transplantation Study Groupen_US
dc.typeArticleen_US

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