Decreased anxiety-like behavior in a selectively bred high nicotine-preferring rat line

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dc.authorscopusid58698409200
dc.authorscopusid57234009800
dc.authorscopusid6602810147
dc.authorscopusid7003864010
dc.authorscopusid13404482300
dc.authorscopusid6603344109
dc.authorscopusid35275498700
dc.contributor.authorBayoglu, M.
dc.contributor.authorOzturk, Bintepe, M.
dc.contributor.authorKanit, L.
dc.contributor.authorBalkan, B.
dc.contributor.authorGozen, O.
dc.contributor.authorKoylu, E.O.
dc.contributor.authorKeser, A.
dc.date.accessioned2024-08-25T18:31:48Z
dc.date.available2024-08-25T18:31:48Z
dc.date.issued2023
dc.departmentEge Üniversitesien_US
dc.description.abstractGenetic vulnerability contributes significantly to the individual variability observed in nicotine dependence. Selective breeding for sensitivity to a particular effect of abused drugs has produced rodent lines useful for studying genetic vulnerability to drug addiction. Previous research showed that anxiety-related personality traits are associated with nicotine dependence. Therefore, we examined the differences in anxiety-like behavior between a high nicotine-preferring rat line and their controls. At the beginning of the study, all rats, naïve to any drug, were exposed sequentially to open field arena, marble-burying and elevated plus-maze paradigms. In the second step, all rats received nicotine in drinking water for 7 weeks. Behavioral tests were rerun on the final 2 weeks of chronic nicotine treatment. Elevated plus-maze testings under basal condition and during chronic nicotine treatment showed that the time spent on the open arms, preference for being in the open arms, and the latency to enter the closed arms were higher, whereas open arm avoidance index was lower in nicotine-preferring rats compared to the controls. In the open field test, nicotine-preferring rats spent longer time in the central zone and excreted less fecal pellets; they buried less marbles in the marble-burying test. These findings indicate a lower level of anxiety-like behavior in nicotine-preferring rat line under basal conditions and during chronic nicotine treatment. We conclude that lower anxiety level in nicotine-preferring rat line is consistent with novelty-seeking personality type and may increase vulnerability to nicotine dependence in this rat line. © 2023 Informa UK Limited, trading as Taylor & Francis Group.en_US
dc.identifier.doi10.1080/00207454.2023.2279505
dc.identifier.issn0020-7454
dc.identifier.pmid37929683en_US
dc.identifier.scopus2-s2.0-85176932551en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1080/00207454.2023.2279505
dc.identifier.urihttps://hdl.handle.net/11454/100008
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor and Francis Ltd.en_US
dc.relation.ispartofInternational Journal of Neuroscienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240825_Gen_US
dc.subjectaddictionen_US
dc.subjectanxietyen_US
dc.subjectNicotineen_US
dc.subjectnovelty-seekingen_US
dc.subjectselective breedingen_US
dc.titleDecreased anxiety-like behavior in a selectively bred high nicotine-preferring rat lineen_US
dc.typeArticleen_US

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