CHA2DS2-VASc score and modified CHA2DS2-VASc score can predict mortality and intensive care unit hospitalization in COVID-19 patients

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dc.contributor.authorGunduz, Ramazan
dc.contributor.authorYildiz, Bekir Serhat
dc.contributor.authorOzdemir, Ibrahim Halil
dc.contributor.authorCetin, Nurullah
dc.contributor.authorOzen, Mehmet Burak
dc.contributor.authorBakir, Eren Ozan
dc.contributor.authorBayturan, Ozgur
dc.date.accessioned2021-05-03T20:21:35Z
dc.date.available2021-05-03T20:21:35Z
dc.date.issued2021
dc.departmentEge Üniversitesien_US
dc.description.abstractIn this study, we investigated whether the CHA2DS2-VASc score could be used to estimate the need for hospitalization in the intensive care unit (ICU), the length of stay in the ICU, and mortality in patients with COVID-19. Patients admitted to Merkezefendi State Hospital because of COVID-19 diagnosis confirmed by RNA detection of virus by using polymerase chain reaction between March 24, 2020 and July 6, 2020, were screened retrospectively. The CHA2DS2-VASc and modified CHA2DS2-VASc score of all patients was calculated. Also, we received all patients' complete biochemical markers including D-dimer, Troponin I, and c-reactive protein on admission. We enrolled 1000 patients; 791 were admitted to the general medical service and 209 to the ICU; 82 of these 209 patients died. The ROC curves of the CHA2DS2-VASc and M-CHA2DS2-VASc scores were analyzed. The cut-off values of these scores for predicting mortality were >= 3 (2 or under and 3). The CHA2DS2-VASc and M-CHA2DS2-VASc scores had an area under the curve value of 0.89 on the ROC. The sensitivity and specificity of the CHA2DS2-VASc scores were 81.7% and 83.8%, respectively; the sensitivity and specificity of the M-CHA2DS2-VASc scores were 85.3% and 84.1%, respectively. Multivariate logistic regression analysis showed that CHA2DS2-VASc, Troponin I, D-Dimer, and CRP were independent predictors of mortality in COVID-19 patients. Using a simple and easily available scoring system, CHA2DS2-VASc and M-CHA2DS2-VASc scores can be assessed in patients diagnosed with COVID-19. These scores can predict mortality and the need for ICU hospitalization in these patients.en_US
dc.identifier.doi10.1007/s11239-021-02427-1en_US
dc.identifier.issn0929-5305
dc.identifier.issn1573-742X
dc.identifier.pmid33730303en_US
dc.identifier.scopus2-s2.0-85102960265en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1007/s11239-021-02427-1
dc.identifier.urihttps://hdl.handle.net/11454/69387
dc.identifier.wosWOS:000629886800001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofJournal of Thrombosis and Thrombolysisen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCHA2DS2-VASc scoreen_US
dc.subjectModified CHA2DS2-VASc scoreen_US
dc.subjectCOVID-19en_US
dc.subjectMortalityen_US
dc.subjectIntensive care unit hospitalizationen_US
dc.titleCHA2DS2-VASc score and modified CHA2DS2-VASc score can predict mortality and intensive care unit hospitalization in COVID-19 patientsen_US
dc.typeArticleen_US

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