Dual nuclear/fluorescence imaging potantial of zinc(II) phthalocyanine in MIA PaCa-2 cell line

Basit Öğe Kaydı
dc.contributor.authorLambrecht F.Y.
dc.contributor.authorInce M.
dc.contributor.authorEr O.
dc.contributor.authorOcakoglu K.
dc.contributor.authorSarı F.A.
dc.contributor.authorKayabasi C.
dc.contributor.authorGunduz C.
dc.date.accessioned2019-10-27T08:20:23Z
dc.date.available2019-10-27T08:20:23Z
dc.date.issued2016
dc.departmentEge Üniversitesien_US
dc.description.abstractBackground and Objective: Pancreatic cancer is very common and difficult to diagnose in early stage. Imaging systems for diagnosing cancer have many disadvantages. However, combining different imaging modalities offers synergistic advantages. Optical imaging is the most multidirectional and widely used imaging modality in both clinical practice and research. Methods: In present study, Zinc(II) phthalocyanine [Zn(II)Pc] was synthesized, labeled with iodine- 131 and in vitro study was carried out. The intracellular uptake studies of radiolabeled Zn(II)Pc were performed in WI-38 [ATCC CCL-75™, tissue: human fibroblast lung] and MIA PaCa-2 [ATCC CRL-1420™, tissue: human epithelial pancreas carcinoma] cell lines. Results: The intracellular uptake efficiency of radiolabeled Zn(II)Pc in MIA PaCa-2 cells was determined two times higher than WI-38 cells. Also, fluorescence imaging (FI) efficiency of synthesized Zn(II)Pc was investigated in MIA PaCa-2 cells and significant uptake was observed. Conclusion: Zn(II)Pc might be used as a new agent for dual fluorescence/nuclear imaging for pancreatic cancer. © 2016 Bentham Science Publishers.en_US
dc.identifier.doi10.2174/1874471009666160628083416en_US
dc.identifier.endpage227en_US
dc.identifier.issn1874-4710
dc.identifier.issue3en_US
dc.identifier.pmid27363481en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage222en_US
dc.identifier.urihttps://doi.org/10.2174/1874471009666160628083416
dc.identifier.urihttps://hdl.handle.net/11454/25624
dc.identifier.volume9en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherBentham Science Publishers B.V.en_US
dc.relation.ispartofCurrent Radiopharmaceuticalsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject131Ien_US
dc.subjectFluorescence imagingen_US
dc.subjectMRIen_US
dc.subjectNuclear imagingen_US
dc.subjectPancreatic canceren_US
dc.subjectZinc(II) Phthalocyanineen_US
dc.titleDual nuclear/fluorescence imaging potantial of zinc(II) phthalocyanine in MIA PaCa-2 cell lineen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

Scopus İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu