Melatonin strongly interacts with zwitterionic model membranes - evidence from Fourier transform infrared spectroscopy and differential scanning calorimetry

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dc.contributor.authorSevercan, F
dc.contributor.authorSahin, I
dc.contributor.authorKazanci, N
dc.date.accessioned2019-10-27T18:58:42Z
dc.date.available2019-10-27T18:58:42Z
dc.date.issued2005
dc.departmentEge Üniversitesien_US
dc.description.abstractInteractions of melatonin with zwitterionic dipalmitoyl phosphatidylcholine (DPPC) multilamellar liposomes (MLVs) were investigated as a function of temperature and melatonin concentration (1-30 mol%) by using two noninvasive techniques, namely Fourier transform infrared (FTIR) spectroscopy and differential scanning calorimetry (DSC). The investigation of the C-H, C=O, and PO2- antisymmetric double stretching modes in FTIR spectra and DSC studies reveal that melatonin changes the physical properties of the DPPC bilayers by decreasing the main phase transition temperature, abolishing the pretransition, ordering the system in the gel phase, and increasing the dynamics of the system both in the gel and liquid crystalline phases. It also causes significant decrease in the wavenumber for the C=O stretching and PO2- antisymmetric double bond stretching bands, which indicates strong hydrogen bonding The results imply that melatonin locates in the interfacial region of the membrane. Furthermore, in the DSC curve, more than one signal is observed at high melatonin concentrations (24 and 30 mol%), which indicates melatonin-induced phase separation in DPPC membranes. (C) 2005 Elsevier B.V. All rights reserved.en_US
dc.identifier.doi10.1016/j.bbamem.2004.12.009en_US
dc.identifier.endpage222en_US
dc.identifier.issn0005-2736
dc.identifier.issn0006-3002
dc.identifier.issue2en_US
dc.identifier.pmid15737332en_US
dc.identifier.startpage215en_US
dc.identifier.urihttps://doi.org/10.1016/j.bbamem.2004.12.009
dc.identifier.urihttps://hdl.handle.net/11454/37528
dc.identifier.volume1668en_US
dc.identifier.wosWOS:000227458700007en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Bven_US
dc.relation.ispartofBiochimica Et Biophysica Acta-Biomembranesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectmelatoninen_US
dc.subjectdipalmitoyl phosphatidylcholineen_US
dc.subjectmembraneen_US
dc.subjectliposomeen_US
dc.subjectFourier transform infrareden_US
dc.subjectdifferential scanning calorimetryen_US
dc.subjectphase separationen_US
dc.titleMelatonin strongly interacts with zwitterionic model membranes - evidence from Fourier transform infrared spectroscopy and differential scanning calorimetryen_US
dc.typeArticleen_US

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