The negative impact of levothyroxine treatment on urinary luteinizing hormone measurements in pediatric patients with thyroid disease

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dc.authorscopusid7102184457
dc.authorscopusid26643511300
dc.authorscopusid6603825651
dc.authorscopusid56363623300
dc.authorscopusid36049932900
dc.authorscopusid56259567900
dc.authorscopusid9745968400
dc.contributor.authorDemir, And
dc.contributor.authorBöber, Ece
dc.contributor.authorDarcan, Şükran
dc.contributor.authorAydın, Adem
dc.contributor.authorStenman, Ulf-Hakan
dc.contributor.authorBüyükgebiz, Atilla
dc.contributor.authorHero, Matti
dc.date.accessioned2024-08-25T18:47:34Z
dc.date.available2024-08-25T18:47:34Z
dc.date.issued2023
dc.departmentEge Üniversitesien_US
dc.description.abstractObjectives: Previous studies suggest urinary luteinizing hormone (LH) and follicle-stimulating hormone (FSH) measurements by immunofluorometric assays (IFMA) as noninvasive alternatives to serum assays for puberty assessment. However, these studies excluded patients with other endocrine disorders and those taking medications. Besides, the recent discontinuation of IFMA manufacturing is a concern. We explored the utility of luminometric assays (LIA) for urinary gonadotropins and thyroid-stimulating hormone (TSH) determinations in euthyroid patients with thyroid pathologies.Methods: We used LIA and IFMA assays to measure serum and first-morning-voided (FMV) urine LH, FSH, and TSH concentrations in euthyroid patients with various thyroid disorders. Of the 47 euthyroid patients with normal serum TSH (S-TSH) levels, 14 were receiving levothyroxine therapy.Results: FMV total urinary LH (U-LH) concentrations correlated significantly with those measured in serum using either LIA (r=0.67, P<.001) or IFMA (r=0.83, P=.003) in patients not receiving levothyroxine treatment; however, no significant correlation could be detected in patients receiving levothyroxine regardless of the assay method (for LIA: r=0.50, P=.08 and IFMA r=0.44, P=.15). Urinary TSH (U-TSH) concentrations correlated poorly with those in serum in both the untreated and the treated groups (r=-0.13, P=.49, and r=-0.45, P=.11, respectively).Conclusion: FMV total U-LH determinations by LIA can be used to assess pubertal development in patients with thyroid pathology, provided the euthyroid patient is not on levothyroxine treatment. U-TSH measurements by LIA cannot replace invasive S-TSH measurements at least in patients with normal S-TSH levels. Further research may reveal the utility of U-TSH determinations in patients with elevated S-TSH levels.en_US
dc.description.sponsorshipSuomen Lketieteen Sti10.13039/100008723en_US
dc.description.sponsorshipNo Statement Availableen_US
dc.identifier.doi10.3389/fendo.2023.1236710
dc.identifier.issn1664-2392
dc.identifier.pmid38161981en_US
dc.identifier.scopus2-s2.0-85180682729en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.3389/fendo.2023.1236710
dc.identifier.urihttps://hdl.handle.net/11454/101966
dc.identifier.volume14en_US
dc.identifier.wosWOS:001130475400001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherFrontiers Media Saen_US
dc.relation.ispartofFrontiers in Endocrinologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz20240825_Gen_US
dc.subjectluteinizing hormoneen_US
dc.subjectfollicle-stimulating hormoneen_US
dc.subjectthyroid-stimulating hormoneen_US
dc.subjecturinary gonadotropinsen_US
dc.subjectlevothyroxineen_US
dc.subjectFollicle-Stimulating-Hormoneen_US
dc.subjectGonadotropin Measurementsen_US
dc.subjectMetabolismen_US
dc.subjectDisordersen_US
dc.subjectSecretionen_US
dc.subjectChildrenen_US
dc.subjectIncreaseen_US
dc.subjectPubertyen_US
dc.subjectWomenen_US
dc.subjectSerumen_US
dc.titleThe negative impact of levothyroxine treatment on urinary luteinizing hormone measurements in pediatric patients with thyroid diseaseen_US
dc.typeArticleen_US

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