The influence of juvenile hormone analogue, fenoxycarb on the midgut remodeling in Bombyx mori (L., 1758) (Lepidoptera: Bombycidae) during larval-pupal metamorphosis

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dc.contributor.authorGoncu, Ebru
dc.contributor.authorParlak, Osman
dc.date.accessioned2019-10-27T21:25:55Z
dc.date.available2019-10-27T21:25:55Z
dc.date.issued2011
dc.departmentEge Üniversitesien_US
dc.description.abstractDuring larval-pupal metamorphosis, midgut tissues of holometabolous insects undergo remodeling and this remodeling process involves two metamorphic events. Degeneration of larval midgut occurs via programmed cell death and pupal midgut develops from regenerative (stem) cells. All metamorphic events in insects are regulated by ecdysone and juvenile hormone. Molecular mechanisms of ecdysone are well known but action mechanism of juvenile hormone is not well understood. Fenoxycarb, 0-ethyl N-(2-(4-pheoxyphenoxy)-ethyl) carbamate has been previously shown one of the most potent juvenile hormone analogue against a variety of insect species and widely used for investigations the mechanisms of juvenile hormone. In this study, we aimed to analyze the metamorphic events in the midgut of Bombyx mori Linnaeus, 1758 and investigate the effects of fenoxycarb on this period. For this purpose, we applied two different doses of fenoxycarb (1ng/10 mu l and 10ng/10 mu l) topically on day 0 of fifth instar larvae. We followed the progression of remodeling processes with morphological observations and analyzed programmed cell death specific proteins, caspase 3 for apoptosis and acid phosphatase for autophagic cell death in control and experiment groups. Our results indicated that, programmed cell death of larval midgut has morphologic characteristics of apoptosis and caspase activation occurs during this period and juvenile hormone analogue fenoxycarb inhibits or delays remodeling process in dose dependent manner.en_US
dc.description.sponsorshipEge UniversityEge Universityen_US
dc.description.sponsorshipThe research was supported by Ege University (2009 Science 021).en_US
dc.identifier.endpage194en_US
dc.identifier.issn1010-6960
dc.identifier.issue2en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage179en_US
dc.identifier.urihttps://hdl.handle.net/11454/44891
dc.identifier.volume35en_US
dc.identifier.wosWOS:000292377300002en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherEntomological Soc Turkey, Ege Univen_US
dc.relation.ispartofTurkiye Entomoloji Dergisi-Turkish Journal of Entomologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectApoptosisen_US
dc.subjectautophagic cell deathen_US
dc.subjectBombyx morien_US
dc.subjectfenoxycarben_US
dc.subjectmidguten_US
dc.titleThe influence of juvenile hormone analogue, fenoxycarb on the midgut remodeling in Bombyx mori (L., 1758) (Lepidoptera: Bombycidae) during larval-pupal metamorphosisen_US
dc.typeArticleen_US

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