Assessment of Prognostic Factors and Validity of Scoring Models in Childhood Autoimmune Encephalitis

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dc.authoridcetin, ipek/0000-0002-1820-8980
dc.authorscopusid57205023509
dc.authorscopusid36571118200
dc.authorscopusid58139850600
dc.authorscopusid58139639700
dc.authorscopusid57699214800
dc.authorscopusid57189047650
dc.authorscopusid55638300200
dc.authorwosidcetin, ipek/ABI-4233-2020
dc.contributor.authorKanmaz, Seda
dc.contributor.authorYilmaz, Sanem
dc.contributor.authorToprak, Dilara Ece
dc.contributor.authorAtas, Yavuz
dc.contributor.authorInce, Tugce
dc.contributor.authorSimsek, Erdem
dc.contributor.authorDokurel, Ipek
dc.date.accessioned2024-08-25T18:53:18Z
dc.date.available2024-08-25T18:53:18Z
dc.date.issued2023
dc.departmentEge Üniversitesien_US
dc.description.abstractObjective: The aim of this study is to evaluate the prognostic factors in a single-center pediatric cohort with autoimmune encephalitis. Materials and Methods: The study group consisted of 23 pediatric autoimmune encephalitis patients (seropositive autoimmune encephalitis: 15, seronegative autoimmune encephalitis: 8). Five group prognostic parameters were evaluated: clinical manifestations, electroenc ephalography features, magnetic resonance imaging characteristics, biomarkers, and treatment modalities. Three scoring models were applied: the Antibody Prevalence in Epilepsy and Response to Immunotherapy in Epilepsy for predicting autoimmune-related epilepsy in the whole cohort and the anti-N-methyl-d-aspartate receptor Encephalitis 1-Year Functional Status score for overall outcome in patients with anti-N-methyl-d-aspartate receptor encephalitis. Results: The initial clinical spectrum of the disease was similar in the seronegative and seropositive groups. Almost half of the patients (48%) recovered without any complications with first-line immunotherapy. The patients with movement disorders in the acute phase of the disease needed more likely second-line immunotherapy (P =.039). The presence of status epilepticus at admission was significantly associated with adverse outcomes and the development of autoimmune-related epilepsy (P =.019). Autoimmune-related epilepsy was defined in an equal proportion of patients (91.5%) with 2 immune epilepsy scores (Antibody Prevalence in Epilepsy and Response to Immunotherapy in Epilepsy). The N-methyl-d-aspartate receptor Encephalitis 1-Year Functional Status score and the modified Rankin score assessed for the first-year prognosis were strongly correlated among the patients with anti-N-methyl-d-aspartate receptor encephalitis (P =.03, Spearmen's rho = 0.751). Conclusions: The presence of status epilepticus was the most important prognostic factor in the patients with the adverse outcome. The studied scoring models (Anti-N-methyl-d-aspartate receptor Encephalitis 1-Year Functional Status, Antibody Prevalence in Epilepsy, and Response to Immunotherapy in Epilepsy) have also been proven to be applicable to the pediatric age group for predicting overall outcome and autoimmune-related epilepsy.en_US
dc.identifier.doi10.5152/TurkArchPediatr.2023.22198
dc.identifier.endpage153en_US
dc.identifier.issn2757-6256
dc.identifier.issue2en_US
dc.identifier.pmid36856351en_US
dc.identifier.scopus2-s2.0-85149942769en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage142en_US
dc.identifier.urihttps://doi.org/10.5152/TurkArchPediatr.2023.22198
dc.identifier.urihttps://hdl.handle.net/11454/103019
dc.identifier.volume58en_US
dc.identifier.wosWOS:000962416600005en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAVESen_US
dc.relation.ispartofTurkish Archives of Pediatricsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz20240825_Gen_US
dc.subjectAnti-NMDAR encephalitisen_US
dc.subjectautoimmune encephalitisen_US
dc.subjectimmune epilepsyen_US
dc.subjectoutcomeen_US
dc.subjectprognostic factorsen_US
dc.subjectAspartate Receptor Encephalitisen_US
dc.subjectDiagnosisen_US
dc.subjectChildrenen_US
dc.titleAssessment of Prognostic Factors and Validity of Scoring Models in Childhood Autoimmune Encephalitisen_US
dc.typeArticleen_US

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