microRNA biosensors: Opportunities and challenges among conventional and commercially available techniques

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dc.contributor.authorKilic, Tugba
dc.contributor.authorErdem, Arzum
dc.contributor.authorOzsoz, Mehmet
dc.contributor.authorCarrara, Sandro
dc.date.accessioned2019-10-27T10:43:23Z
dc.date.available2019-10-27T10:43:23Z
dc.date.issued2018
dc.departmentEge Üniversitesien_US
dc.description.abstractAs being the most extensively studied, non-coding, evolutionary conserved, post-transcriptional gene regulators of genome, microRNAs (miRNAs) have taken great attention among various disciplines due to their important roles in biological processes and link with cancer. Due to their diagnostic value, there have been many conventional methods used in detection of miRNAs including northern blotting, quantitative real time PCR (qRT-PCR) and microarray technology besides novel techniques based on various nanotechnology approaches and molecular biology tools including miRNA biosensors. The aim of this review is to explain the importance of miRNAs in biomedical field with an emphasis on early cancer diagnosis by overviewing both research based and commercially available miRNA detection methods in the last decade considering their strengths and weakness with an emphasis on miRNA biosensors.en_US
dc.description.sponsorshipMarie CurieEuropean Union (EU)en_US
dc.description.sponsorshipDr. Kilic acknowledges the Horizon 2020, Marie Sklodowska-Curie actions, EPFL fellows international postdoctoral fellowship program co-funded by Marie Curie.en_US
dc.identifier.doi10.1016/j.bios.2017.08.007en_US
dc.identifier.endpage546en_US
dc.identifier.issn0956-5663
dc.identifier.issn1873-4235
dc.identifier.pmid28823978en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage525en_US
dc.identifier.urihttps://doi.org/10.1016/j.bios.2017.08.007
dc.identifier.urihttps://hdl.handle.net/11454/30763
dc.identifier.volume99en_US
dc.identifier.wosWOS:000413284200071en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Advanced Technologyen_US
dc.relation.ispartofBiosensors & Bioelectronicsen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectmiRNAen_US
dc.subjectBiosensorsen_US
dc.subjectCanceren_US
dc.subjectEmerging technologiesen_US
dc.titlemicroRNA biosensors: Opportunities and challenges among conventional and commercially available techniquesen_US
dc.typeReview Articleen_US

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