The investigation of relationship between joint findings and serum angiogenic and inflammatory factor levels in severe hemophilia A patients

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dc.contributor.authorKarapinar, Tuba H.
dc.contributor.authorKaradas, Nihal
dc.contributor.authorOzek, Gulcihan
dc.contributor.authorTufekci, Ozlem
dc.contributor.authorAtabay, Berna
dc.contributor.authorTurker, Meral
dc.contributor.authorYuksel, Faize
dc.contributor.authorKarapinar, Deniz Y.
dc.contributor.authorVergin, Canan
dc.contributor.authorIrken, Gulersu
dc.contributor.authorOren, Hale
dc.date.accessioned2019-10-27T22:12:55Z
dc.date.available2019-10-27T22:12:55Z
dc.date.issued2014
dc.departmentEge Üniversitesien_US
dc.description.abstractDespite the use of primary prophylactic Factor VIII replacement in severe hemophilia A patients, bleeding into joints cannot be prevented completely and early diagnosis and treatment of the joint bleedings are important for prevention of permanent joint damage. Recent studies have shown that neoangiogenesis plays important role in development of synovitis after recurrent joint bleedings. This study aimed to investigate the relationship between joint findings and levels of serum angiogenic and inflammatory factors in severe hemophilia A patients.The patient groups consisted of 10 severe hemophilia A patients with acute joint bleeding and 25 severe hemophilia A patients without acute joint bleeding. They were all inhibitor negative. The control group consisted of 22 healthy male children. Complete blood cell count analysis, C-reactive protein (CRP), serum ferritin, lactic acid, and ELISA-based detection of vascular endothelial growth factor (VEGF), intercellular adhesion molecule-1, thrombomodulin, macrophage migration inhibitory factor (Min, and endostatin were performed from peripheral blood of patient and the control groups. CRP and M IF levels were detected significantly higher in hemophilia patients with acute joint bleeding than patients without acute joint bleeding. There was a positive correlation between serum thrombomodulin, VEGF, and MIF levels. In this study, we demonstrated that serum CRP and MIF levels increases in acute bleeding period regardless of the presence of previous joint damage in children with severe hemophilia. CRP elevation may be a useful and rapid marker for acute bleeding in these patients. Blood Coagul Fibrinolysis 25:703-708 2014 (C) Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.en_US
dc.description.sponsorshipDokuz Eylul University Research FundDokuz Eylul Universityen_US
dc.description.sponsorshipThis study was supported by Dokuz Eylul University Research Fund.en_US
dc.identifier.doi10.1097/MBC.0000000000000131en_US
dc.identifier.endpage708en_US
dc.identifier.issn0957-5235
dc.identifier.issn1473-5733
dc.identifier.issue7en_US
dc.identifier.pmid24850210en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage703en_US
dc.identifier.urihttps://doi.org/10.1097/MBC.0000000000000131
dc.identifier.urihttps://hdl.handle.net/11454/49636
dc.identifier.volume25en_US
dc.identifier.wosWOS:000343097300010en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofBlood Coagulation & Fibrinolysisen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectangiogenesisen_US
dc.subjectchildrenen_US
dc.subjecthemarthrosisen_US
dc.subjecthemophiliaen_US
dc.subjectinflammatory factorsen_US
dc.titleThe investigation of relationship between joint findings and serum angiogenic and inflammatory factor levels in severe hemophilia A patientsen_US
dc.typeArticleen_US

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