Evaluation of the Radiation Dose-Volume Effects of Optic Nerves and Chiasm by Psychophysical, Electrophysiologic Tests, and Optical Coherence Tomography in Nasopharyngeal Carcinoma

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dc.contributor.authorAkagunduz, Ozlem Ozkaya
dc.contributor.authorYilmaz, Suzan Guven
dc.contributor.authorYalman, Deniz
dc.contributor.authorYuce, Berna
dc.contributor.authorBiler, Elif Demirkilinc
dc.contributor.authorAfrashi, Filiz
dc.contributor.authorEsassolak, Mustafa
dc.date.accessioned2019-10-27T10:47:31Z
dc.date.available2019-10-27T10:47:31Z
dc.date.issued2017
dc.departmentEge Üniversitesien_US
dc.description.abstractPurpose: To evaluate the radiation dose-volume effects of optic nerves and chiasm by visual psychophysical, electrophysiologic tests, and optical coherence tomography in patients with locally advanced nasopharyngeal carcinoma. Materials and Methods: A series of visual tests including visual acuity, visual field, contrast sensitivity, visual evoked potential, and optical coherence tomography were administered to 20 patients with locally advanced (T3-T4) nasopharyngeal carcinoma who were treated with definitive chemoradiotherapy. Volume that received 55 Gy (V-55), mean dose (D-mean), highest dose to 5% of the volume (D-5), and maximum dose (D-max) for optic nerves and chiasm were evaluated for each patient. Cutoff values were identified as V-55: 50%, D-mean: 50 Gy, D-5: 55 Gy, and D-max: 60 Gy. The effects of radiation dose-volume on ophthalmologic tests were evaluated. Results: Ophthalmological evaluation revealed optic neuropathy with simultaneous retinopathy in 6 eyes of 4 patients and radiation retinopathy alone in both eyes of 1 patient. Regarding radiation dose-volume effects of the optic nerve, significant detrimental effect of all parameters was observed on visual acuity. Visual field and contrast sensitivity were affected significantly with V-55 50% and D-mean 50 Gy. Visual evoked potential latency was affected significantly with D-mean 50 Gy, D-5 55 Gy, and D-max 60 Gy. For the chiasm, significant detrimental effect of all parameters was observed on visual acuity as well. Retinal nerve fiber layer thickness and visual evoked potential amplitude were not affected by any of the dose-volume parameters neither optic nerves nor chiasm. Conclusion: The volume receiving the threshold dose, mean dose, and 5% of the volume receiving the maximum dose are important parameters besides maximum dose to optic nerves and chiasm. A comprehensive ophthalmological evaluation including visual field, contrast sensitivity, visual evoked potential latency, and amplitude should be performed for these patients. Visual evoked potential latency is an objective predictor of vision loss before the onset of clinical signs.en_US
dc.identifier.doi10.1177/1533034617711613en_US
dc.identifier.endpage977en_US
dc.identifier.issn1533-0346
dc.identifier.issn1533-0338
dc.identifier.issue6en_US
dc.identifier.pmid28585489en_US
dc.identifier.startpage969en_US
dc.identifier.urihttps://doi.org/10.1177/1533034617711613
dc.identifier.urihttps://hdl.handle.net/11454/31432
dc.identifier.volume16en_US
dc.identifier.wosWOS:000418867900037en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSage Publications Incen_US
dc.relation.ispartofTechnology in Cancer Research & Treatmenten_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectradiation dose-volume effectsen_US
dc.subjectoptic nerves and chiasmen_US
dc.subjectradiation optic neuropathyen_US
dc.subjectelectrophysiologic testsen_US
dc.subjectanterior visual pathwaysen_US
dc.titleEvaluation of the Radiation Dose-Volume Effects of Optic Nerves and Chiasm by Psychophysical, Electrophysiologic Tests, and Optical Coherence Tomography in Nasopharyngeal Carcinomaen_US
dc.typeArticleen_US

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