Carbapenem-resistant Gram-negative pathogens associated with septic shock: a review of 120 cases

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dc.authoridbaskol, dilsah/0000-0001-5910-5227
dc.authorscopusid57204010130
dc.authorscopusid57199151189
dc.authorscopusid57489737700
dc.authorscopusid57376118600
dc.authorscopusid57671523300
dc.authorscopusid57223272699
dc.authorscopusid57436649900
dc.authorwosidBozbiyik, Osman/GRR-8533-2022
dc.authorwosidd, d/HGD-9247-2022
dc.authorwosidSipahi, Oguz Resat/AAR-2916-2020
dc.authorwosidAkyol, Deniz/HGB-7894-2022
dc.contributor.authorOnal, Ugur
dc.contributor.authorAkyol, Deniz
dc.contributor.authorMert, Merve
dc.contributor.authorBaskol, Dilsah
dc.contributor.authorMemetali, Seichan Chousein
dc.contributor.authorSanlidag, Gamze
dc.contributor.authorKenanoglu, Buse
dc.date.accessioned2023-01-12T19:59:43Z
dc.date.available2023-01-12T19:59:43Z
dc.date.issued2022
dc.departmentN/A/Departmenten_US
dc.description.abstractThis study aimed to evaluate the influencing variables for outcomes in patients with septic shock having culture-proven carbapenem-resistant Gram-negative pathogens. It included 120 patients (mean age 64.29 +/- 1.35 years and 58.3% female). The mean Sequential Organ Failure Assessment score during septic shock diagnosis was found to be 11.22 +/- 0.43 and 9 +/- 0.79 among the patients with mortality and among the survivors, respectively (P = 0.017). The logistic regression analysis showed that empirical treatment as mono Gram-negative bacteria-oriented antibiotic therapy (P = 0.016, odds ratio (OR) = 17.730, 95% confidence interval (CI): 1.728-182.691), Charlson Comorbidity Index >2 (P = 0.032, OR = 7.312, 95% CI: 5.7-18.3), and systemic inflammatory response syndrome score 3 or 4 during septic shock diagnosis (P = 0.014, OR = 5.675, 95% CI: 1.424-22.619) were found as independent risk factors for day 30 mortality. Despite early diagnosis and effective management of patients with septic shock, the mortality rates are quite high in CRGNP-infected patients.en_US
dc.identifier.doi10.1080/1120009X.2022.2064703
dc.identifier.endpage445en_US
dc.identifier.issn1120-009X
dc.identifier.issn1973-9478
dc.identifier.issue7en_US
dc.identifier.pmid35446235en_US
dc.identifier.scopus2-s2.0-85129627372en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage436en_US
dc.identifier.urihttps://doi.org/10.1080/1120009X.2022.2064703
dc.identifier.urihttps://hdl.handle.net/11454/77222
dc.identifier.volume34en_US
dc.identifier.wosWOS:000784492200001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofJournal of Chemotherapyen_US
dc.relation.publicationcategoryDiğeren_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCarbapenem resistanceen_US
dc.subjectGram-negative pathogensen_US
dc.subjectseptic shocken_US
dc.subjectInfectious-Diseases-Societyen_US
dc.subjectClinical-Practice Guidelinesen_US
dc.subjectManagementen_US
dc.subjectMortalityen_US
dc.subjectSepsisen_US
dc.subjectPneumoniaen_US
dc.subjectDiagnosisen_US
dc.subjectAdultsen_US
dc.titleCarbapenem-resistant Gram-negative pathogens associated with septic shock: a review of 120 casesen_US
dc.typeReviewen_US

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